Hemorheological changes dependent on the time from the onset of ischemic stroke

Kowal, P; Marcinkowska‐Gapińska, Anna

doi:10.1016/j.jns.2007.03.011

Cited by 35 publications

(47 citation statements)

References 9 publications

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“…It is also in agreement with some literature data [12] where increased red cells aggregability accompanied by decreased deformability was reported. Such combination may lead to creation of unordered packets of red cells which can result in hindered blood ow.…”

Section: Rheological Parametersupporting

confidence: 93%

“…These results corroborate with other our results obtained for this group of patients [9]. Comparison of current results with the data obtained for patients with remote ischemic episode [12] indicates an increase of plasma viscosity and whole blood relative viscosity in the group of patients in the acute phase of ischemic stroke with respect to the patients with remote ischemic episode.…”

Section: Rheological Parametersupporting

confidence: 93%

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Analysis of Complex Viscosity in a Group of Patients with Circulation Disorders

Marcinkowska‐Gapińska¹,

Kowal²

2012

Acta Phys. Pol. A

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Rheology of viscoelastic uids is a complex phenomenon. Full blood is an example of a body uid of non-Newtonian character with pronounced viscoelastic properties. Blood ow in the circulatory system depends not only on the physical and physico-chemical properties of blood but also on the structure and properties of the vascular system. Blood viscosity is one of the most important factor determining the blood ow. Its value depends on the shear rate, hematocrit, erythrocyte aggregability and deformability, and on the plasma viscosity and composition. In the course of the investigation we utilized oscillatory methods, called also dynamic mechanical analysis. The technique principle is based on the measurement of the amplitude and phase of oscillations of the sample subject to a harmonic force with certain amplitude and frequency. The results of dynamic mechanical analysis were used to determine the viscoelastic properties of blood samples. We performed also the standard ow curve measurements of the blood plasma samples, that is shear stress as a function of shear rate in the rotary mode. All measurements were performed by means of a Contraves LS-40 rheometer on blood samples taken from two groups of patients. One group contained patients after heart attack, while the second one after cerebral infarction. In none of the groups the patients were in an acute state. Information obtained from oscillatory measurements indicate increased erythrocyte aggregability in both groups of patients.

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Section: Rheological Parametersupporting

confidence: 93%

Section: Rheological Parametersupporting

confidence: 93%

Analysis of Complex Viscosity in a Group of Patients with Circulation Disorders

Marcinkowska‐Gapińska¹,

Kowal²

2012

Acta Phys. Pol. A

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“…[15][16][17][18][19] Previous studies mostly analyzed blood viscosity in a group combining all ischemic stroke subtypes.…”

Section: Discussionmentioning

confidence: 99%

“…DOA, 2-3D, 1W, and 2W stand for the date of admission, 2-3 days after admission, 1 week after admission, and 2 weeks after admission, respectively. Change in mean values of blood viscosity and the blood cell count in each stroke subtype group from 19 the date of admission to 2 weeks after. The circle, triangle, and rectangle indicate SAO, LAA, and CE, respectively.…”

Section: Figure2mentioning

confidence: 99%

“…[11][12][13][14] An increase in blood viscosity has been identified in the acute phase of ischemic stroke, similar to other thrombotic diseases. [15][16][17][18][19] However, actual 4 measurements of blood viscosity have not been performed because of the stereotypical belief that blood viscosity increases equally in all ischemic stroke subtypes, which is within expectations and with less clinical value. However, since the measurement of blood viscosity may provide useful information on differential diagnoses, treatments, and the prevention of stroke, it needs to be examined more extensively.…”

Section: Introductionmentioning

confidence: 99%

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Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Furukawa

Abumiya

Sakai

et al. 2016

Journal of Stroke and Cerebrovascular Diseases

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Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke

et al. 2021

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Whole blood viscosity (WBV) is the intrinsic resistance to flow developed due to the frictional force between adjacent layers of flowing blood. Elevated WBV is an independent risk factor for stroke. Poor microcirculation due to elevated WBV can prevent adequate perfusion of the brain and might act as an important secondary factor for hypoperfusion in acute ischaemic stroke. In the present study, we examined the association of WBV with basal cerebral perfusion assessed by CT perfusion in acute ischaemic stroke. Confirmed acute ischemic stroke patients (n = 82) presenting in hours were recruited from the single centre. Patients underwent baseline multimodal CT (non-contrast CT, CT angiography and CT perfusion). Where clinically warranted, patients also underwent follow-up DWI. WBV was measured in duplicate within 2 h after sampling from 5-mL EDTA blood sample. WBV was significantly correlated with CT perfusion parameters such as perfusion lesion volume, ischemic core volume and mismatch ratio; DWI volume and baseline NIHSS. In a multivariate linear regression model, WBV significantly predicted acute perfusion lesion volume, core volume and mismatch ratio after adjusting for the effect of occlusion site and collateral status. Association of WBV with hypoperfusion (increased perfusion lesion volume, ischaemic core volume and mismatch ratio) suggest the role of erythrocyte rheology in cerebral haemodynamic of acute ischemic stroke. The present findings open new possibilities for therapeutic strategies targeting erythrocyte rheology to improve cerebral microcirculation in stroke.

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Hemorheological changes dependent on the time from the onset of ischemic stroke

Cited by 35 publications

References 9 publications

Analysis of Complex Viscosity in a Group of Patients with Circulation Disorders

Analysis of Complex Viscosity in a Group of Patients with Circulation Disorders

Increased Blood Viscosity in Ischemic Stroke Patients with Small Artery Occlusion Measured by an Electromagnetic Spinning Sphere Viscometer

Whole blood viscosity is associated with baseline cerebral perfusion in acute ischemic stroke

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