Hemorheological effects of amlodipine in spontaneously hypertensive rats

Shamanaev, Aleksandr; Алиев, О. И.; Анищенко, А. М.; Sidehmenova, Anastasia V; Плотников, М. Б.

doi:10.4103/ijp.ijp_176_16

Cited by 3 publications

(2 citation statements)

References 13 publications

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“…Given the absence of a relationship between RBC deformability and systolic BP value in our hypertensive animals, changes in blood plasma composition could be more responsible for the blood pressure elevation in the hypertensive state that neutralizes the expected effect resulting from changes in RBC properties. This hypothesis is consistent with the previously observed higher plasma viscosity in SHRs [53].…”

Section: Relations Between Blood Pressure Value and Erythrocyte Param...supporting

confidence: 94%

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Radošinská

Kollárová

Jasenovec

et al. 2023

Biology

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Erythrocyte deformability, crucial for oxygen delivery to tissues, plays an important role in the etiology of various diseases. As the factor maintaining the erythrocyte deformability, nitric oxide (NO) has been identified. Reduced NO bioavailability also plays a role in the pathogenesis of hypertension. Our aim was to determine whether aging and hypertension affect erythrocyte deformability and NO production by erythrocytes in experimental animals divided into six groups according to age (7, 20 and 52 weeks), labeled WKY-7, WKY-20 and WKY-52 for normotensive Wistar-Kyoto (WKY) rats, and SHR-7, SHR-20 and SHR-52 for spontaneously hypertensive rats (SHR). The filtration method for the determination of erythrocyte deformability and the fluorescent probe DAF-2 DA for NO production were applied. Deformability and NO production by erythrocytes increased at a younger age, while a decrease in both parameters was observed at an older age. Strain-related differences in deformability were observed at 7 and 52 weeks of age. SHR-7 had reduced deformability and SHR-52 had increased deformability compared with age-matched WKY. Changes in NO production under hypertensive conditions are an unlikely primary factor affecting erythrocyte deformability, whereas age-related changes in deformability are at least partially associated with changes in NO production. However, an interpretation of data obtained in erythrocyte parameters observed in SHRs of human hypertension requires precaution.

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Section: Relations Between Blood Pressure Value and Erythrocyte Param...supporting

confidence: 94%

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Radošinská

Kollárová

Jasenovec

et al. 2023

Biology

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“…In an animal study conducted on spontaneously hypertensive rats, administration of intragastric amlodipine at a dose of 10 mg/kg for 6 weeks resulted in a significant decrease in mean blood pressure by 29% but had no effect on PV, PFIB concentration, RBC aggregation, and RBC deformability 23 . This study contradicts our finding, but this study was performed in rats, and dose of amlodipine used was very high (10 mg/kg), which may cause profound hypotension, leading to activation of counter regulatory mechanisms, such as the renin–angiotensin system.…”

Section: Discussionmentioning

confidence: 98%

Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?

Ravindra

Arunkumar

Puniyani

et al. 2019

Indian Heart Journal

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BackgroundDespite several decades of use of calcium channel blockers, the side effect of edema persists as a class effect, and its mechanism is unresolved. Amlodipine has effects on hemorheology (HR), and its hemodilutory property may partly contribute to its antihypertensive action. This aspect is not well studied, and the literature is sparse in this regard.ObjectiveThis experiment was planned to determine effect of a single-dose administration of amlodipine on HR parameters in normal human volunteers.Methods and resultsAmlodipine (5 mg) or S (-) amlodipine (2.5 mg) was administered to 27 normal human volunteers. Whole-blood viscosity (WBV) at different shear rates, plasma viscosity (PV), red cell rigidity (RCR), red cell aggregation (RCA), hematocrit (Hct), plasma hemoglobin, along with plasma drug concentration were determined at time intervals, t = 0, 4, 8, 12, and 24 h. Statistically significant reductions were observed at tmax = 4 h in WBV at shear rates of 0.512 s–1 (p < 0.005), WBV at shear rates of 5.26 s–1 (p < 0.01), PV (p < 0.05), and Hct (p < 0.01). At t = 8 h, as drug concentration reduced, some of the changes persisted and later slowly decreased with the decreasing drug concentration till t = 24 h. Red blood cell–related parameters such as RCA and RCR remained unaltered. WBV values at all shear rates, when corrected for Hct = 0.45, did not show deviation from their original values at any time.ConclusionsAmlodipine causes a reduction in Hct and blood viscosity, along with hemodilution. These effects persist as long as the drug remains in plasma. Edema resulting from chronic dosing may be explained by the aforementioned effects. It is possible that antihypertensive action of the drug may be due to a combination of vasodilatation and an improvement in the HR properties.

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Clinical Impact of Hemorheology on Subclinical Myocardial Injury in Patients with Hypertension

Hatori¹

2018

J Clin Med Res

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BackgroundThe blood concentration of high-sensitivity cardiac troponin T (hs-cTnT) is a useful biomarker for myocardial injury or the pathogenesis of hypertension. Little is known about the relationship between hemorheology and myocardial injury in patients with hypertension. This cross-sectional study aimed to clarify the clinical impact of hemorheology on subclinical myocardial injury assessed with a microchannel array flow analyzer (MC-FAN) and its impact on hs-cTnT in patients with hypertension.MethodsA total of 447 outpatients (men: 181; women: 266; mean age: 65 ± 13 years), with no history of cardiovascular disease, including admission for heart failure, who were undergoing treatment for hypertension, were enrolled. Whole blood passage time (WBPT) as a marker of hemorheology was measured with a MC-FAN, and the relationship between hs-cTnT levels and various clinical parameters, including WBPT, was examined.Resultshs-cTnT levels were detected in 400 patients (89.5%). WBPT was significantly higher in patients with detectable hs-cTnT levels than in those with undetectable hs-cTnT levels (60.5 ± 16.8 s versus 50.2 ± 14.2 s, P < 0.001). In patients with detectable hs-cTnT levels, there was a significant positive correlation between WBPT and hs-cTnT level (r = 0.33; P < 0.001). Multiple regression analysis revealed that WBPT was an independent variable when hs-cTnT was a subordinate factor (β = 0.15; P < 0.01). Receiver-operating characteristic curve analysis indicated that a cutoff value for WBPT of 55.6 s yielded the largest area under the curve (0.744; P < 0.001) for discriminating high hs-cTnT levels as ≥ 0.014 ng/mL.ConclusionThe results indicate that WBPT is independently associated with hs-cTnT in hypertensive patients with no history of cardiovascular events, suggesting that impairment of hemorheology in small cardiac vessels causes subclinical myocardial injury. In addition, the study suggests that progression of myocardial injury can be prevented by maintaining WBPT at approximately ≤ 55 s.

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Hemorheological effects of amlodipine in spontaneously hypertensive rats

Cited by 3 publications

References 13 publications

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Amlodipine alters hemorheological parameters: Increased efficacy at the cost of edema?

Clinical Impact of Hemorheology on Subclinical Myocardial Injury in Patients with Hypertension

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