Hemorrhagic Conversion of Acute Ischemic Stroke

Zubair, Adeel S.; Sheth, Kevin N

doi:10.1007/s13311-023-01377-1

Cited by 14 publications

(3 citation statements)

References 117 publications

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“…In addition, although drugs targeting the mechanisms of ischemic brain injury have been identified in experimental stroke models, clinical trials have not yielded the same positive results as those seen in animal studies 182 . Clinical translation in the field of ischemic stroke is fraught with difficulties 183,184 . On the one hand, it may be due to the gap in animal models.…”

Section: Discussionmentioning

confidence: 99%

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Perspective from single‐cell sequencing: Is inflammation in acute ischemic stroke beneficial or detrimental?

Deng,

Hu,

Zhou

et al. 2023

CNS Neurosci Ther

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BackgroundAcute ischemic stroke (AIS) is a common cerebrovascular event associated with high incidence, disability, and poor prognosis. Studies have shown that various cell types, including microglia, astrocytes, oligodendrocytes, neurons, and neutrophils, play complex roles in the early stages of AIS and significantly affect its prognosis. Thus, a comprehensive understanding of the mechanisms of action of these cells will be beneficial for improving stroke prognosis. With the rapid development of single‐cell sequencing technology, researchers have explored the pathophysiological mechanisms underlying AIS at the single‐cell level.MethodWe systematically summarize the latest research on single‐cell sequencing in AIS.ResultIn this review, we summarize the phenotypes and functions of microglia, astrocytes, oligodendrocytes, neurons, neutrophils, monocytes, and lymphocytes, as well as their respective subtypes, at different time points following AIS. In particular, we focused on the crosstalk between microglia and astrocytes, oligodendrocytes, and neurons. Our findings reveal diverse and sometimes opposing roles within the same cell type, with the possibility of interconversion between different subclusters.ConclusionThis review offers a pioneering exploration of the functions of various glial cells and cell subclusters after AIS, shedding light on their regulatory mechanisms that facilitate the transformation of detrimental cell subclusters towards those that are beneficial for improving the prognosis of AIS. This approach has the potential to advance the discovery of new specific targets and the development of drugs, thus representing a significant breakthrough in addressing the challenges in AIS treatment.

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Section: Discussionmentioning

confidence: 99%

“… 182 Clinical translation in the field of ischemic stroke is fraught with difficulties. 183 , 184 On the one hand, it may be due to the gap in animal models. The current main experimental animal is rats.…”

Section: Discussionmentioning

confidence: 99%

Perspective from single‐cell sequencing: Is inflammation in acute ischemic stroke beneficial or detrimental?

Deng,

Hu,

Zhou

et al. 2023

CNS Neurosci Ther

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“…The blood-brain barrier (BBB) dysfunction is vital in cerebral ischemia-reperfusion injury and HT [13][14][15]. Early BBB disruption predicts HT and poor outcomes in acute stroke patients receiving EVT [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs and mRNA Regulatory Network of Parenchymal Hematoma after Endovascular Mechanical Reperfusion for Acute Ischemic Stroke in Rat

Zhuang,

Huang,

Qin

et al. 2024

Preprint

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Hemorrhagic transformation after endovascular thrombectomy predicts poor outcomes in acute ischemic stroke with large vessel occlusion. The roles of microRNAs in the pathogenesis of parenchymal hematoma (PH) are still unclear. This study aims to investigate the microRNA and mRNA regulatory network associated with PH after mechanical reperfusion in the animal stroke model and oxygen-glucose deprivation/reoxygenation (OGD/R) model. Twenty-five microRNAs were assessed in the reperfusion-induced hemorrhage model in rats with hyperglycemic conditions receiving 5-hour middle cerebral artery occlusion. Thirteen down-regulated microRNAs (miRNA-29a-5p, miRNA-29c-3p, miRNA-126a-5p, miRNA-132-3p, miRNA-136-3p, miRNA-142-3p, miRNA-153-5p, miRNA-218a-5p, miRNA-219a-2-3p, miRNA-369-5p, miRNA-376a-5p, miRNA-376b-5p, miRNA-383-5p) and one up-regulated microRNA (miRNA-195-3p) were found in rat peri-infarct with PH. Ten of these 14 PH-related microRNAs were significantly differentially expressed in at least two of five models of neuron, astrocyte, microglia, BMEC, and pericyte after OGD/R, consistent with the animal model results. Thirty-one predicted hub target genes were significantly differentially expressed in rat peri-infarct with PH. Forty-nine microRNA-mRNA regulatory axes of PH were revealed, which were related to the mechanisms of oxidative stress, apoptosis, immune, and inflammation. Simultaneously differentially expressed microRNAs and related genes in several cells of the neurovascular unit may serve as valuable targets for PH after endovascular thrombectomy in acute ischemic stroke.

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Optical coherence tomography enables longitudinal evaluation of cell graft-directed remodeling in stroke lesions

Adewumi,

Simkulet,

Küreli

et al. 2025

Experimental Neurology

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Hemorrhagic Conversion of Acute Ischemic Stroke

Cited by 14 publications

References 117 publications

Perspective from single‐cell sequencing: Is inflammation in acute ischemic stroke beneficial or detrimental?

Perspective from single‐cell sequencing: Is inflammation in acute ischemic stroke beneficial or detrimental?

MicroRNAs and mRNA Regulatory Network of Parenchymal Hematoma after Endovascular Mechanical Reperfusion for Acute Ischemic Stroke in Rat

Optical coherence tomography enables longitudinal evaluation of cell graft-directed remodeling in stroke lesions

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