Hemorrhagic encephalopathy in dengue shock syndrome: a case report

Souza, Luíz José de; Martins, André Luiz; Paravidini, Paulo César Leitão; Nogueira, Rita Maria Ribeiro; Neto, Carlos Gicovate; Bastos, Diogo Assed; Siqueira, Edno Wallace da Silva; Carneiro, Rodrigo da Costa

doi:10.1590/s1413-86702005000300009

Cited by 37 publications

(25 citation statements)

References 6 publications

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“…Our observation concurs with previous findings of cerebral [8,9] and macular haemorrhages [10] in patients with acute dengue infection. We highlight the importance of recognising dengue infection in patients who present with strokelike episodes, and who originate from countries where dengue is endemic.…”

supporting

confidence: 93%

Dysarthria-clumsy hand syndrome associated with dengue type-2 infection

Seet

Lim

2007

J Neurol

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supporting

confidence: 93%

Dysarthria-clumsy hand syndrome associated with dengue type-2 infection

Seet

Lim

2007

J Neurol

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“…In Brazil, atypical manifestations of dengue infection, such as hepatitis, myocarditis and encephalitis, have been observed during epidemics that occurred in Ceará in 1994, in the state of Pernambuco in 1997 and in Campos in 2005 [4,7,8].…”

Section: Discussionmentioning

confidence: 99%

The impact of dengue on liver function as evaluated by aminotransferase levels

Souza¹,

Nogueira²,

Soares³

et al. 2007

Braz J Infect Dis

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The objective of this study was to evaluate the impact of dengue virus infection on liver function by measuring aminotransferase in blood samples from patients serologically diagnosed by according to two MAC-ELISA protocols. Degrees of liver damage were classified according to aminotransferase levels: grade A -normal enzyme levels; grade B -increased levels of at least one of the enzymes; grade C -increased, with at least one of the enzymes being at levels higher than three times the upper reference values; grade D -acute hepatitis, with aminotransferase levels at least ten times their normal values. Of the 169 serologically confirmed cases of dengue at the dengue referral center in Campos dos Goytacazes in the state of Rio de Janeiro, Brazil, 65.1% had abnormal aminotransferase levels: 81 cases being classified as grade B, 25 as grade C and 3 as grade D. A further 34.9% of cases had normal enzyme levels and were classified as grade A. Liver damage is a common complication of dengue infection and aminotransferase levels are a valuable marker for monitoring these cases.

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“…In the present study, the majority of dengue cases did not fulfi ll all the criteria for DHF/DSS and dengue was confi rmed only after autopsy completion. In the literature, such cases are usually described as atypical manifestations, published as separate reports, or described as exotic fi ndings after autopsies (27) We found that patients aged >65 years had a high possibility of death, which may be related in part to the high frequency of comorbidities reported in the elderly (38) (39) (40) (41) (42) (43) (44) . Information on comorbidities is not included in the Brazilian Information System for Notifi able Diseases, and this information is obtained only through investigation of fatal dengue cases (40) (42) .…”

Section: Discussionmentioning

confidence: 77%

Evaluation of the World Health Organization 2009 classification of dengue severity in autopsied individuals, during the epidemics of 2011 and 2012 in Brazil

Cavalcanti

Braga

Pompeu

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction:The dengue classifi cation proposed by the World Health Organization (WHO) in 2009 is considered more sensitive than the classifi cation proposed by the WHO in 1997. However, no study has assessed the ability of the WHO 2009 classifi cation to identify dengue deaths among autopsied individuals suspected of having dengue. In the present study, we evaluated the ability of the WHO 2009 classifi cation to identify dengue deaths among autopsied individuals suspected of having dengue in Northeast Brazil, where the disease is endemic. Methods: This retrospective study included 121 autopsied individuals suspected of having dengue in Northeast Brazil during the epidemics of 2011 and 2012. All the autopsied individuals included in this study were confi rmed to have dengue based on the fi ndings of laboratory examinations. Results: The median age of the autopsied individuals was 34 years (range, 1 month to 93 years), and 54.5% of the individuals were males. According to the WHO 1997 classifi cation, 9.1% (11/121) of the cases were classifi ed as dengue hemorrhagic fever (DHF) and 3.3% (4/121) as dengue shock syndrome. The remaining 87.6% (106/121) of the cases were classifi ed as dengue with complications. According to the 2009 classifi cation, 100% (121/121) of the cases were classifi ed as severe dengue. The absence of plasma leakage (58.5%) and platelet counts <100,000/mm 3 (47.2%) were the most frequent reasons for the inability to classify cases as DHF. Conclusions: The WHO 2009 classifi cation is more sensitive than the WHO 1997 classifi cation for identifying dengue deaths among autopsied individuals suspected of having dengue.

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Hemorrhagic encephalopathy in dengue shock syndrome: a case report

Cited by 37 publications

References 6 publications

Dysarthria-clumsy hand syndrome associated with dengue type-2 infection

Dysarthria-clumsy hand syndrome associated with dengue type-2 infection

The impact of dengue on liver function as evaluated by aminotransferase levels

Evaluation of the World Health Organization 2009 classification of dengue severity in autopsied individuals, during the epidemics of 2011 and 2012 in Brazil

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