Hemorrhagic fever with renal syndrome complicated by orchitis

Abstract

Hemorrhagic fever with renal syndrome (HFRS) is a disease caused by viruses of the family Bunyaviridae, genus Hantavirus. HFRS from Dobrava virus (DOBV) is a seldom reported disease in Albania. Clinically HFRS is manifested as mild, moderate, or severe. Therefore, the number of cases of Hantavirus' infection may be underestimated, and should be included in the differential diagnosis of many acute infections, hematologic diseases, acute abdominal diseases and renal diseases complicated by acute renal failure. We report here an atypical presentation of HFRS from Dobrava virus complicated by orchitis with a positive outcome.

A short review of hemorrhagic fever with renal syndrome and it's extrarenal complications

“…11,12 Orchiepididymitis is a very rare complication of HFRS by HNTV/ Dobrava virus infection. 4,13 Other authors such as Eun S Kang, Bui-Mansfield and Bren et al are also suggested by implication of pancreas during HFRS course. [13][14][15] The maternal and fetal outcomes of pregnancy complicated by HFRS have also been reported in China, where the most severe form of HFRS caused by Hantan virus occurs.…”

“…2,8 Neurological, cardiopulmonary hematologic, gastrointestinal, urogenital, ocular and pregnancy complications are prescribe in now days. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] The clinical presentation of many patients included typical symptoms of viral encephalitis and several patients developed serious CNS-related complications. 11,12 Orchiepididymitis is a very rare complication of HFRS by HNTV/ Dobrava virus infection.…”

Posterior Reversible Encephalopathy Syndrome in a Patient with Hemorrhagic Fever with Renal Syndrome

“…In addition to fever and myalgias, early symptoms include headache, chills, dizziness, nonproductive cough, nausea, vomiting, and other gastrointestinal symptoms. Malaise, diarrhea, and lightheadedness are reported by approximately half of all patients, with less frequent reports of arthralgia, back pain, and abdominal pain [1]. Conjunctival, cerebral, and gastrointestinal (GI) hemorrhages occur in about one-third of patients [4].…”

“…e basic pathologic and pathophysiologic disorder in HFRS is capillary damage (vasculitis) [12]. Increased vascular permeability and decreased platelet count are the hallmarks of hantavirus-associated diseases [1].…”

“…Hantaviruses are enveloped RNA viruses and members of the Bunyaviridae family. Hantavirus infection to humans is considered a spill over infection that causes two types of serious illnesses, hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS) [1]. People can also become infected when they touch mouse or rat urine, droppings, or nesting materials that contain the virus and then touch their eyes, nose, or mouth.…”