Hemorrhagic Giant Cell Tumor of the Occipital Skull Base: A Case Report and Literature Review

Abstract

Giant cell tumor of bone is a benign but locally aggressive osteolytic neoplasm that represents 3% to 5% of all primary bone tumors, primarily found at the epiphyses of long bones. Less than 1% are of calvarial origin. Herein, we report a rare case of a nine-year-old girl with a hemorrhagic giant cell tumor of the left occipital skull base.

Surgical management of giant cell tumor invading the occipital bone: A case report and literature review

“…[12] However, some series have reported slight female or male predominance. [21,24,51] In our review of reported cases in the occipital region, most patients were female adults; interestingly, the youngest patient was a 10-day male newborn [Table 1]. GCTB has also been reported in patients with neurofibromatosis, aneurysmal bone cysts, and Paget's disease; however, there is no clear association, and risk factors remain unknown.…”

“…[2,12] Particularly, few cases have been reported in the occipital bone compared to the temporal, frontal, sphenoid, and ethmoidal bones. [4][5][6][7]13,[15][16][17]19,[21][22][23]26,[28][29][30][31]33,37,43,45,[47][48][49]51,[53][54][55] Weng et al reported that the overall distribution of cases in the occipital bone was 9.8%. [51] is tumor is more common among adults, and gender distribution has been previously reported to be more common in females.…”

“…[12] We conducted a review of the literature, which yielded 27 reported cases of GCTB originating in the occipital bone (retrieval of full-text information, including patient sex and age, type of treatment, and presence of recurrence during the follow-up was possible in 22 cases, and is shown in Table 1). [1,4,7,13,[15][16][17][21][22][23]26,[28][29][30][31]33,43,45,[47][48][49]51,54,55] To the best of our knowledge, this is the first case of a GCTB of the occipital bone in a Hispanic patient. Besides, our review constitutes the most comprehensive compilation of cases in the occipital region.…”

“…[ 2 , 12 ] Particularly, few cases have been reported in the occipital bone compared to the temporal, frontal, sphenoid, and ethmoidal bones. [ 4 - 7 , 13 , 15 - 17 , 19 , 21 - 23 , 26 , 28 - 31 , 33 , 37 , 43 , 45 , 47 - 49 , 51 , 53 - 55 ] Weng et al . reported that the overall distribution of cases in the occipital bone was 9.8%.…”