Hemorrhagic Mass-Like Presentation of Vitreoretinal Lymphoma

Abstract

<b><i>Purpose:</i></b> The aim of this study was to report the presentation, treatment, and outcomes of vitreoretinal lymphoma (VRL) associated with hemorrhagic mass-like lesions (HMLs) in the retina. <b><i>Methods:</i></b> This study was a retrospective analysis of patients with HMLs associated with VRL seen at a single tertiary referral center. For each patient, the clinical charts, the fundus imaging, and the treatment outcomes were reviewed. <b><i>Results:</i></b> Three eyes of 2 patients had VRL with HMLs. In all study eyes, HMLs were preceded by an area of retinitis-like retinal infiltration and evolved into elevated hemorrhagic masses. Two eyes had multiple relapses with HMLs. All HMLs regressed with treatment and were replaced by extensive chorioretinal atrophy. <b><i>Conclusion:</i></b> VRL can present with HMLs. HMLs seem to correspond to massive intraretinal infiltration by VRL, mimicking a solid mass. Despite response to therapy, HMLs are associated with poor anatomical and functional outcomes.

Vitreoretinal lymphoma presenting as frosted branch angiitis in a patient with diffuse large B-cell lymphoma

“…Diagnosing vitreoretinal lymphoma is also time-sensitive, because subretinal and sub-RPE infiltrates can be rapidly increase in size leading to hemorrhagic masses and retinal detachments if not treated expediently. 16 Lymphoma infiltration of the optic disc can also lead to a poor prognosis if not treated promptly. 9 …”