Hemorrhagic Pericardial Effusion with Tamponade: A Rare Adverse Effect of Infliximab—Case Report and Literature Review

Lather, Henry D.; Kahlenberg, J. Michelle

doi:10.1155/2016/2576496

Cited by 10 publications

(10 citation statements)

References 14 publications

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“…The diagnosis of drug‐induced pericarditis is often difficult. Typical symptoms include dyspnoea, fever, chest pain and cough and can be associated with leukocytosis and markedly elevated C‐reactive protein miming viral or bacterial aetiology . Additionally, patients on infliximab are at increased risk of infection because of drug‐related immunosuppression.…”

Section: What Is Known and Study Objectivementioning

confidence: 99%

Pericarditis during infliximab therapy in paediatric ulcerative colitis

et al. 2017

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Section: What Is Known and Study Objectivementioning

confidence: 99%

Pericarditis during infliximab therapy in paediatric ulcerative colitis

et al. 2017

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“…The treatment of ATIL is based upon the cessation of the offending agent. In severe cases, steroids and immunosuppressive agents have also shown to be effective [2]. Alternate therapy is then chosen for the underlying immunological or rheumatological disorder, which in our patient was Ulcerative Colitis.…”

Section: Discussionmentioning

confidence: 94%

Pericardial Effusion Due to Infliximab Therapy for Ulcerative Colitis

Mirza

Murugesan

et al. 2018

American Journal of Gastroenterology

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Ulcerative colitis is characterized by ulcers and inflammation of the inner lining of the gastrointestinal tract. Antitumor necrosis factor alpha (anti-TNF alpha) agents such as infliximab are drugs that have been used for the treatment of ulcerative colitis for decades. Infliximab is known to be associated with various adverse effects including anti-TNF alpha induced lupus (ATIL). We present a rare case of a 51-year-old female with pericardial effusion secondary to infliximab therapy for treatment of her ulcerative colitis. Discontinuation of infliximab led to resolution of the pericardial effusion.

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“…Pericardial effusions have been reported as a possible adverse effect of TNF-α inhibitor use [6–9]. Soh et al reported 2 cases of pericardial effusions in patients on TNF-α therapy, both with surgical drainage.…”

Section: Discussionmentioning

confidence: 99%

Rheumatoid Arthritis and Cardiac Compression Caused by a Large Fibrotic Intrapericardial Mass and Effusion: A Case Report

et al. 2019

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Patient: Female, 58 Final Diagnosis: Pericardial effusion and mass Symptoms: Fatigue • lower extremity edema • shortness of breath Medication: — Clinical Procedure: Pericardiocentesis Specialty: Rheumatology Objective: Unknown ethiology Background: Pericarditis is common in rheumatoid arthritis, mostly occurring as an extra-articular manifestation of the disease. We describe a patient with stable rheumatoid arthritis who presented with a large pericardial effusion and a compressive fibrotic pericardial mass. The patient had recently started treatment with a tumor necrosis factor-alpha (TNF-α) antagonist. Case Report: The patient was a 58-year-old woman with rheumatoid arthritis who presented with right ventricular compression caused by a pericardial fibrotic mass and a large pericardial effusion. The patient did not have active arthritis at the time of presentation. She had been started on treatment with a tumor necrosis factor-alpha (TNF-α) antagonist 4 months prior to this presentation. She was successfully treated with surgical pericardiectomy and resection of the pericardial mass. Pathologic analysis of the pericardial mass demonstrated fibrosis and no evidence of active inflammation, rheumatoid arthritis, opportunistic infection, or malignancy. Conclusions: We describe a patient with stable rheumatoid arthritis who developed subacute right heart compression syndrome secondary to pericardial effusion and fibrous pericardial mass. The exact cause of pericarditis and the pericardial mass remain uncertain. There is a need for increased awareness of the association between use of TNF-α antagonists and the possible development of an intrapericardial fibrotic mass and effusion.

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Hemorrhagic Pericardial Effusion with Tamponade: A Rare Adverse Effect of Infliximab—Case Report and Literature Review

Cited by 10 publications

References 14 publications

Pericarditis during infliximab therapy in paediatric ulcerative colitis

Pericarditis during infliximab therapy in paediatric ulcerative colitis

Pericardial Effusion Due to Infliximab Therapy for Ulcerative Colitis

Rheumatoid Arthritis and Cardiac Compression Caused by a Large Fibrotic Intrapericardial Mass and Effusion: A Case Report

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