Hemorrhagic Syndrome Induced by Contact with Caterpillars of the Genus Lonomia (Saturniidae, Hemileucinae)

Kelen, E.M.A.; Picarelli, Zuleika P.; Duarte, Alaour Candida

doi:10.3109/15569549509019465

Cited by 84 publications

(90 citation statements)

References 18 publications

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“…Marked alterations of blood clotting, including decreased fibrinogen, factor V, factor XIII, plasminogen, and ␣ 2 anti-plasmin, and increases in fibrinolytic activity, fibrinogen degradation products and activated thrombin may occur. [1][2][3][4][5][6] Attempts at reversing these clinical manifestations with anti-fibrinolytic drugs such as aprotinin and ⑀-aminocaproic acid associated with whole blood, freshfrozen plasma or cryoprecipitates, failed and indeed instead of reversing exacerbated them. 1,7 We and others have shown that L. obliqua caterpillar bristle extracts retain biological properties such as procoagulant activity, [2][3][4]8,9 complement (C) activation and phospholipase A 2 activity (Rocha-Campos AC and others, unpublished data).…”

Section: Introductionmentioning

confidence: 99%

Specific heterologous F(ab')2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars.

Rocha-Campos¹,

Gonçalves²,

Higashi³

et al. 2001

Am J Trop Med Hyg

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Abstract. Contact with Lonomia obliqua caterpillars results in a bleeding syndrome characterized by hemorrhage and blood coagulation disturbances. Conventional therapy using antifibrinolytics or cryoprecipitates has been unable to treat pathophysiologic alterations. As antivenoms are effective therapy for treatment of victims of venomous animals, a process of manufacturing a specific antilonomic serum by immunizing horses with Lonomia caterpillar bristle extracts (LBE) was developed. Lonomia caterpillar bristle extracts exhibited several protein bands on SDS-PAGE, induced blood coagulation abnormalities and lethality in mice, and stimulated specific antibody production in horses. Sera obtained from immunized horses were rich in anti-LBE specific antibodies distributed among the horse IgG isotypes. These antibodies had the ability to recognize various LBE antigens as well as to neutralize their coagulopathy-inducing activity. The antivenom manufactured by the developed process was composed of purified and sterilized F(abЈ) 2 with ED 50 ϭ 38.61 l, potency ϭ 0.29 mg / ml, and 95% confidence limit of potency 0.20-1.36.

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Section: Introductionmentioning

confidence: 99%

Specific heterologous F(ab')2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars.

Rocha-Campos¹,

Gonçalves²,

Higashi³

et al. 2001

Am J Trop Med Hyg

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“…The primary symptoms characterizing accidental contact with Lonomia obliqua caterpillars are severe hemorrhage and acute renal failure (Kelen et al, 1995). The coagulation disorder presented by these patients appears to be related to the action of many caterpillar toxins acting in a redundant manner on the hemostatic system.…”

Section: Obliqua Venomous Components: Insights For Their Role In Tmentioning

confidence: 99%

“…Some lepidopteran larvae, notably those of the family Saturniidae, also produce venoms that adversely impact hemostasis. Unlike snake and spider venoms, caterpillar venoms are used solely for defense against predators, which are envenomed by touching the bristles of the caterpillars (Kelen et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

“…caterpillars are known for causing a hemorrhagic syndrome characterized by ecchymoses, hematuria, bleeding from scars and mucous membranes, intracerebral bleeding and acute renal failure (Arocha-Piñango and Guerrero, 2001). In southern Brazil, accidents caused by L. obliqua caterpillars are reportedly increasing (Kelen et al, 1995). Accidents usually occur when the victim, leaning against tree trunks containing dozens or hundreds of caterpillars, comes into contact with the bristles of the caterpillars.…”

Section: Introductionmentioning

confidence: 99%

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A catalog for the transcripts from the venomous structures of the caterpillar Lonomia obliqua: Identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome

Veiga

Ribeiro

Guimarães

et al. 2005

Gene

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Accidents with the caterpillar Lonomia obliqua are often associated with a coagulation disorder and hemorrhagic syndrome in humans. In the present study, we have constructed cDNA libraries from two venomous structures of the caterpillar, namely the tegument and the bristle. Highthroughput sequencing and bioinformatics analyses were performed in parallel. Over one thousand cDNAs were obtained and clustered to produce a database of 538 contigs and singletons (clusters) for the tegument library and 368 for the bristle library. We have thus identified dozens of fulllength cDNAs coding for proteins with sequence homology to snake venom prothrombin activator, trypsin-like enzymes, blood coagulation factors and prophenoloxidase cascade activators. We also report cDNA coding for cysteine proteases, Group III phospholipase A2, Ctype lectins, lipocalins, in addition to protease inhibitors including serpins, Kazal-type inhibitors, cystatins and trypsin inhibitor-like molecules. Antibacterial proteins and housekeeping genes are also described. A significant number of sequences were devoid of database matches, suggesting that their biologic function remains to be defined. We also report the N-terminus of the most abundant proteins present in the bristle, tegument, hemolymph, and "cryosecretion". Thus, we have created a catalog that contains the predicted molecular weight, isoelectric point, accession number, and putative function for each selected molecule from the venomous structures of L. obliqua. The role of these molecules in the coagulation disorder and hemorrhagic syndrome caused by envenomation with this caterpillar is discussed. All sequence information and the Supplemental Data, including Figures and Tables with hyperlinks to FASTA-formatted files for each contig and the best match to the Databases, are available at http://www.ncbi.nih.gov/projects/omes.

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“…As lagartas apresentam estruturas urticantes, causando dermatites ou até mesmo acidentes hemorrágicos que podem resultar em óbitos (Duarte et al, 1990). No que tange ao grau de importância econômica e médica, as principais espécies são Lonomia obliqua Walker, com registros preferencialmente nas regiões Sul, Sudeste e Norte do Brasil além dos países Uruguai, Paraguai e Argentina e Lonomia achelous (Cramer), com distribuição na Venezuela, Guiana, Norte do Brasil e Minas Gerais (Fraiha et al, 1986;Kelen et al, 1995). Moraes (2009) cita a ocorrência de L. obliqua, L. achelous e Lonomia descimoni Lemaire no estado do Acre.…”

unclassified

INFESTAÇÃO DE Lonomia sp. (LEPIDOPTERA: SATURNIIDAE) EM SERINGAL DE CULTIVO NO ESTADO DO ACRE

Santos¹,

Oliveira²,

Sutil³

et al. 2015

Agrotropica

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Os lepidópteros possuem importância econômica considerável, pois em sua fase jovem, as lagartas da maioria das espécies são fitófagas e muitas se constituem em pragas sérias das plantas cultivadas. O objetivo desta publicação foi documentar o ataque de lagartas do gênero Lonomia, popularmente conhecidas como "lagartas-defogo", causando desfolha em seringal de cultivo, no município de Bujari, AC. Este é o primeiro relato de lagartas deste gênero causando intenso desfolhamento em seringais de cultivo no Acre. Palavras-chave:Hevea brasiliensis, herbivoria, mariposa, surto de insetos.Infestation of Lonomia sp. (Lepidoptera: Saturniidae) in rubber tree cultivation in the state of Acre. The lepidopterans have considerable economic importance. At their young stage the caterpillars of most species are phytophagous and many of them are important pests of cultivated plants. This work aimed to record the infestation of Lonomia, popularly known as urticant caterpillars, causing defoliation in rubber tree cultivation in the county of Bujari, Acre state, Brazil. This is the first report of this caterpillar genus causing heavy defoliation in rubber tree cultivation in Acre state.

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Hemorrhagic Syndrome Induced by Contact with Caterpillars of the Genus Lonomia (Saturniidae, Hemileucinae)

Cited by 84 publications

References 18 publications

Specific heterologous F(ab')2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars.

Specific heterologous F(ab')2 antibodies revert blood incoagulability resulting from envenoming by Lonomia obliqua caterpillars.

A catalog for the transcripts from the venomous structures of the caterpillar Lonomia obliqua: Identification of the proteins potentially involved in the coagulation disorder and hemorrhagic syndrome

INFESTAÇÃO DE Lonomia sp. (LEPIDOPTERA: SATURNIIDAE) EM SERINGAL DE CULTIVO NO ESTADO DO ACRE

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