Hemosiderosis in cirrhosis: A study of 447 native livers

Prevalence of the C282Y mutation of the hemochromatosis gene in liver transplant recipients and donors

“…Hemosiderosis is a well-recognized feature of end-stage liver disease of various etiologies, including alcoholic cirrhosis, 3,7 hepatitis C, 3,7,10,11 and ␣ 1 -antitrypsin deficiency. 7,14 Usually, iron does not accumulate to levels seen in the cirrhotic stage of hereditary hemochromatosis in these diseases.…”

“…7 Recent studies have shown that there is an increased prevalence of the C282Y mutation in patients with porphyria cutanea tarda, a disorder of heme metabolism associated with hepatic hemosiderosis. 8,9 Heterozygosity for hemochromatosis has also been considered to be a risk factor in previous studies of patients with hepatitis C, 3,7,[10][11][12] alcoholic liver disease, 3,7 nonalcoholic steatohepatitis, 13 and ␣ 1 -antitrypsin deficiency. 14 Also, in some hemochromatosis pedigrees, C282Y heterozygotes or compound heterozygotes may, albeit uncommonly, have hemosiderosis in the range of C282Y homozygotes.…”

Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions

“…Table 3 shows the correlation of iron with grade and stage. Two plus iron was seen in one of the three biopsies with cirrhosis and may be an example of the iron accumulation known to occur in other, nonhemochromatosis forms of cirrhosis (22). Patients with known hereditary hemochromatosis were excluded from this review to exclude the inflammation and fibrosis that result from sideronecrosis.…”

Iron overload syndromes and the liver

“…Third, as discussed above, it should be kept in mind that the index was originally applied to cases of early hemochromatosis and must be interpreted cautiously in patients with advanced chronic liver disease as 'false positive' hepatic iron indices in cirrhosis are common. 31 As measurement of hepatic iron concentration is not always available, Deugnier et al 42 have investigated the utility of a histologic hepatic iron index based on detailed and systematic grading of iron deposits in various locations of the liver lobule. In their hands, this provided similar results to biochemically determined HII.…”