Hemostasis

Saliba, Zakhia; Slaba, S.; Sawan, Elie B.

doi:10.1007/978-88-470-5681-7_13

Cited by 1 publication

(3 citation statements)

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“…7,16 Antiphospholipid syndrome, genetic susceptibility, and other acquired prothrombotic disorders such as pregnancy, postpartum period, contraceptive pills, malignancy, infection, and trauma are major risk factors for developing CVST. [24][25][26][27][28] The pathogenesis of cerebral venous sinus thrombosis may be inferred to include two distinct processes. Intracranial…”

Section: Discussionmentioning

confidence: 99%

“…The vast majority of patients can go through both of these mechanisms simultaneously. [23][24][25][26][27][28][29][30][31][32][33][34] Elevated D-Dimer levels are often used as a standard for measuring the coagulation process. However, medical and physical conditions may affect plasma D-Dimer levels.…”

mentioning

confidence: 99%

“…6,7,36 Diagnosing CVST is complicated by patients' often-atypical symptoms, a wide range of risk factors, and thrombus often develops in the brain's veins and sinuses. 4,5,[23][24][25][26][27][28][29][30][31][32] DSA is a gold standard for identifying vascular diseases like thrombosis, aneurysms, and ulcerative plaques. DSA is essential to determine the diagnosis of CVST.…”

mentioning

confidence: 99%

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D-Dimer Level Associated with Amount of Sinus involvement Using Digital Subtraction Angiography on Cerebral Venous Thrombosis Patients

Amalia¹

2023

JBM

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Background: Cerebral venous sinus thrombosis (CVST) is a form of the cerebrovascular disease characterized by varying degrees of obstruction of veins and cerebral sinuses caused by thrombus. Diagnosis is incredibly challenging due to the wide variety of symptoms and the distinct radiological aspects of affected vessels. In patients with venous thrombosis, the presence of D-Dimer is used as an indicator of the presence of endogenous fibrinolysis. D-Dimer is a by-product of fibrin polymer fragmentation. Objective: To investigate the relationship between the level of D-Dimer and the number of sinuses in CVST by Digital Subtraction Angiography (DSA). Methods: Retrospective data from September 2021 to September 2022 were used in this analytical observational with a crosssectional study design. Chi-Square is used for data processing relationship analysis. Results: Out of the 54 subjects with elevated levels of D-Dimer, 38 (70.4%) are females, whereas 16 (29.6%) are males. High levels of D-Dimer have been related to a greater risk of sinus thrombosis (p < 0.001). D-Dimer levels were similarly shown to rise in conjunction with the number of sinuses most severely damaged by thrombosis. The most common site for thrombosis to develop in this study were the left sigmoid and left transverse sinuses. Most risk factors were hormonal. Conclusion:There is a statistically significant relationship between an increase in the D-Dimer level and the greater number of sinuses involved as determined by DSA in individuals diagnosed with CVST.

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