Hemostatic activity screening and skin toxicity of sap of Jatropha multifida L. (Euphorbiaceae) used in traditional medicine (Benin)

Dougnon, Victorien; Robert, K; Dougnon, Jacques; Segbo, Julien; Jean-Marc, Atègbo; Loko, Frédéric; Dramane, K.

doi:10.1016/j.toxlet.2013.05.560

Cited by 2 publications

(2 citation statements)

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“…An aqueous extract of Pouteria sapota seeds lacked dermal irritation in rabbits and showed mild reversible eye irritation in rabbits [ 122 ]. Jatropha multifida sap did not induce skin lesions in rats after 14 days of treatment [ 164 ]. A diethyl ether extract of Jatropha multifida showed the presence of 16-hydroxyphorbol.…”

Section: Toxicologymentioning

confidence: 99%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The consumption of medicinal plants has notably increased over the past two decades. People consider herbal products as safe because of their natural origin, without taking into consideration whether these plants contain a toxic principle. This represents a serious health problem. A bibliographic search was carried out using published scientific material on native plants from Mexico, Central America, and the Caribbean, which describe the ethnobotanical and toxicological information of medicinal plants empirically considered to be toxic. A total of 216 medicinal plants belonging to 77 families have been reported as toxic. Of these plants, 76 had been studied, and 140 plants lacked studies regarding their toxicological effects. The toxicity of 16 plants species has been reported in clinical cases, particularly in children. From these plants, deaths have been reported with the consumption of Chenopodium ambrosioides, Argemone mexicana, and Thevetia peruviana. In most of the cases, the principle of the plant responsible for the toxicity is unknown. There is limited information about the toxicity of medicinal plants used in Mexico, Central America, and the Caribbean. More toxicological studies are necessary to contribute information about the safe use of the medicinal plants cited in this review.

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Section: Toxicologymentioning

confidence: 99%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Interestingly, it has been shown that medicinal plants have been one of the more important options for treating of various diseases throughout history. In this setting, active ingredients of herbal medicines been employed as a modern treatment methods in bleeding disorders (8,9,15,(20)(21)(22)(23)(24)(25)(26)(27)(28) due to their similarity to in vivo compounds (29)(30)(31). As an example of these natural compounds, there are plant phytoestrogens (32), are similar to 17-b estradiol and estrogens in terms of structure and action, and can bind to estrogen receptors in the body, showing estrogenic effects (33).…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Potential Blood Coagulant Activity ofCaenothus americanus Compounds: Computational Analysis using Docking, Physicochemical, and ADMET Studies

Mashkani,

Yali,

Dorgalaleh

et al. 2023

Preprint

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Caenothus americanus is a common folk remedy for the treatment of wound bleeding. Certain compounds found in this plant have been shown to reduce clotting time. However, analyzing the effects of various compounds of a folk remedy is a time-consuming and expensive process, therefore, this study employed computational analyses using docking, physicochemical, and pharmacokinetic servers to identify potential clotting activity in C.americanus compounds. The ADMETlab, SwissADME web servers, Discovery Studio, and Autodock were used to study the proper binding to target proteins and predict the physicochemical and ADMET properties (adsorption, distribution, metabolism, excretion, and toxicity) of C. americanus compounds. Coagulation factors including activated factor (F) IIa, FVa, FVIIa, FVIIIa, FIXa, FXa, FXIa, FXIIa, and FXIIIa were chosen as target proteins. Docking studies revealed that malic acid, malonic acid, oxalic acid, and succinic acid were effective on coagulation factors, of which, malic acid had better binding to intrinsic pathway factors including FVIIa, FIIa, and FXIIIa (except FVIIIa), oxalic acid to FVIIIa, and malonic acid to FVa and FXa. Moreover, ADMET studies showed the safety profile of these compounds. In conclusion, carboxylic and alcoholic groups of malic acid, malonic acid, oxalic acid and succinic acid play a role in interaction with blood coagulation factors. Additionally, based on the ADMET characteristics and suitable pharmacokinetic potentials of these compounds, they can be introduced as blood coagulant candidates with fewer side effects in bleeding disorders. However, further studies are necessary to evaluate the precise components of the C. americanus with the suability to bind coagulation factors. Keywords: Caenothus americanus, molecular docking, coagulation factors, plant, ADME.

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Hemostatic activity screening and skin toxicity of sap of Jatropha multifida L. (Euphorbiaceae) used in traditional medicine (Benin)

Cited by 2 publications

References 0 publications

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Evaluating the Potential Blood Coagulant Activity ofCaenothus americanus Compounds: Computational Analysis using Docking, Physicochemical, and ADMET Studies

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