Hemostatic, antibacterial and degradable performance of the water-soluble chitosan-coated oxidized regenerated cellulose gauze

He, Jin Mei; Wu, Ya Dong; Wang, Feng Wen; Cheng, Wei; Huang, Yu Dong; Fu, Bo

doi:10.1007/s12221-014-0504-5

Cited by 30 publications

(18 citation statements)

References 14 publications

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“…It shows that the novel OC nanofiber from Nata De Coco has a good potential for further applications such as the medical material or antibacterial material [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Characterization of Nanofiber of Oxidized Cellulose from Nata De Coco

Kotatha

Rungrodnimitchai

2018

International Journal of Chemical Engineering

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Oxidized cellulose (OC) nanofiber was successfully prepared from the dry sheet of Nata De Coco (DNDC) using the mixture system of HNO 3 /H 3 PO 4 -NaNO 2 for the first time. e carboxyl content of the OC was investigated at different conditions (HNO 3 /H 3 PO 4 ratios, reaction times, and reaction temperatures). e results revealed that the carboxyl content of the OC increased along with the reaction time, which yielded 0.6, 14.8, 17.5, 20.9, 21.0, and 21.0% after 0, 6, 12, 36, and 48 hours, respectively. e reaction yields of the OC ranged between 79% and 85% when using HNO 3 /H 3 PO 4 ratio of 1 : 3, 1.4% wt of NaNO 2 at 30°C at different reaction times. From the structural analysis, the OC products showed a nanofibrous structure with a diameter of about 58.3-65.4 nm. e Fourier transform infrared spectra suggested the formation of carboxyl groups in the OC after oxidation reaction. e crystallinity and crystalline index decreased with an increase of reaction time. e decrease of crystallinity from oxidation process agreed with the decrease of degree of polymerization from the hydrolysis of β-1,4-glycosidic linkages in the cellulose structure. e thermal gravimetric analysis results revealed that the OC products were less thermally stable than the raw material of DNDC. In addition, the OC products showed blood agglutinating property by dropping blood on the sample along with excellent antibacterial activity.

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“…It shows that the novel OC nanofiber from Nata De Coco has a good potential for further applications such as the medical material or antibacterial material [38][39][40].…”

Section: Discussionmentioning

confidence: 99%

Synthesis and Characterization of Nanofiber of Oxidized Cellulose from Nata De Coco

Kotatha

Rungrodnimitchai

2018

International Journal of Chemical Engineering

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“…38 The wound was induced by an intersectional cut (0.5 Â 0.5 cm) using a scalpel on the le medial lobe of liver.…”

Section: Evaluation Of Hemostatic Effectmentioning

confidence: 99%

“…The hemostatic behavior of the composite sponges may be mainly related to the structure and properties itself. 38 A lot of water in the blood was absorbed by the SA so that the density and viscosity of blood increased rapidly which made the blood ow slow down and achieved a high blood clotting rate. 46,47 In detail, the amino groups with a positive charge on the CS attracted the negative charge of muramic acid distributed on the surface of the red blood cells.…”

Section: Hemostatic Effectsmentioning

confidence: 99%

Antibacterial and hemostatic performance of chitosan–organic rectorite/alginate composite sponge

Zhang

et al. 2015

RSC Adv.

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This study reports the preparation and properties of a chitosan (CS)-organic rectorite (OREC)/sodium alginate (SA) composite sponge. The novel sponge was fabricated by solution intercalation and chemical cross-linking techniques. The structure and composition of the CS/SA and CS-OREC/SA composite sponges were characterized by FE-SEM, FT-IR, XRD and EDX. The results showed that the polyelectrolyte with a highly cross-linked structure and uniform pore distribution could be obtained by mixing CS and SA with or without the addition of OREC into them. Besides, the low cytotoxicity and excellent antibacterial efficacy of the prepared CS/SA and CS-OREC/SA sponges were demonstrated by an MTT assay and an antibacterial assay. Moreover, the results of the hemostatic tests on ear-artery, earvein and liver injuries of rabbits showed that the addition of OREC into the CS/SA composite sponge significantly improved the hemostatic efficiency of the as-prepared sponge without compromising the biocompatibility and antibacterial property of CS. This study indicated that the CS-OREC/SA composite sponge had the potential to be a potent hemostat for controlling wound infection and bleeding in medical fields.

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“…Consequently, the contact of blood cells with the electropositive material should result in blood clotting and stopping the bleeding. This effect is already used in hemostatic agents based on biological materials, such as oxidized cellulose and chitosan [1,2].…”

Section: Introductionmentioning

confidence: 99%

Investigation of the hemostatic action of low-dimensional electropositive structures

Лернер¹,

Глазкова²,

Psakhie³

et al. 2014

AIP Conference Proceedings

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Abstract. The paper studies the hemostatic action of the fibrous material containing agglomerates of low-dimensional electropositive structures of aluminum oxyhydroxide. The time of parenchymatous bleeding is found to decrease from 292.5 s at spontaneous hemostasis to 177.8 s with the attached fibrous material and to 215.7 s with gauze. The mixed mechanism of the hemostatic action is possible, i.e. along with the hygroscopic mechanism, plateletes aggregate due to destruction of a diffuse part of the double electrical layer in contact with low-dimensional electropositive structures of aluminum oxyhydroxide.

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Hemostatic, antibacterial and degradable performance of the water-soluble chitosan-coated oxidized regenerated cellulose gauze

Cited by 30 publications

References 14 publications

Synthesis and Characterization of Nanofiber of Oxidized Cellulose from Nata De Coco

Synthesis and Characterization of Nanofiber of Oxidized Cellulose from Nata De Coco

Antibacterial and hemostatic performance of chitosan–organic rectorite/alginate composite sponge

Investigation of the hemostatic action of low-dimensional electropositive structures

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