2017
DOI: 10.1186/s12951-017-0296-z
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Hemostatic bioactivity of novel Pollen Typhae Carbonisata-derived carbon quantum dots

Abstract: Background Pollen Typhae Carbonisata (PTC) is a type of calcined herb drug that has been used as a hemostatic medicine to promote hemostasis for thousands of years. In this study, we discovered and separated novel water-soluble carbon quantum dots (CQDs, named PTC-CQDs) from aqueous extracts of PTC. These PTC-CDs were characterized using transmission electron microscopy (TEM) and high-resolution TEM, as well as Fourier transform infrared, ultraviolet–visible, and fluorescence spectroscopy. Then, we assessed th… Show more

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Cited by 77 publications
(74 citation statements)
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“…A range of applications has been developed for emerging nanomaterials including drug delivery [26], biological imaging [27], and optical catalysts [28]. NPs have been reported in other TCMs carbonised at high temperature including Pollen Typhae Carbonisata, Cirsium Setosum Carbonisata, Schizonepetae Herba Carbonisata, and Junci Medulla Carbonisata [5,[29][30][31]. The STC-NPs possessed components similar to those of other widely-studied nanoparticles [32,33].…”
Section: Molecules 2019 24 X For Peer Review 7 Of 13mentioning
confidence: 99%
“…A range of applications has been developed for emerging nanomaterials including drug delivery [26], biological imaging [27], and optical catalysts [28]. NPs have been reported in other TCMs carbonised at high temperature including Pollen Typhae Carbonisata, Cirsium Setosum Carbonisata, Schizonepetae Herba Carbonisata, and Junci Medulla Carbonisata [5,[29][30][31]. The STC-NPs possessed components similar to those of other widely-studied nanoparticles [32,33].…”
Section: Molecules 2019 24 X For Peer Review 7 Of 13mentioning
confidence: 99%
“…To determine whether CSC-CDs are the hemostatic substance in CSC, the mouse tail amputation and liver scratch models were used according to previously published methods. [13][14][15] In brief, Kunming mice were divided into the following groups and subcutaneously injected as indicated: negative control (normal saline, NS); positive control (HC, 0.67 kU kg À1 ); and high-, medium-, and low-dose CSC-CDs (8.33, 3.33, and 1.67 mg kg À1 , respectively). The mouse were anesthetized with 4% pentobarbital sodium via intraperitoneal injection (50.0 mg kg À1 ).…”
Section: Hemostasis Studies Of Csc-cdsmentioning
confidence: 99%
“…However, most of these methods were less environmentally friendly and the processes were tedious. In this research, we developed a novel SSC-CDs with an average diameter of 1.29-6.87 nm and a quantum yield (QY) 6.31% and SSC were prepared by simply burning SS at 350 C for 1 h, according to a modified pyrolysis method [27][28][29]. As a charcoal drug, SSC naturally contained carbon, nitrogen and oxygen, which were necessary for the preparation route of SSC-CDs and might serve both as the carbon source and the passivation agent for CDs.…”
Section: Discussionmentioning
confidence: 99%
“…Nowadays, researches on self-bioactivity of CDs are on the rise [25][26][27][28][29][30], however, more extensive and deep-going explorations of this area are still needed. In this study, we evaluated the component variation and excluded the interference of small molecular organic compounds using an HPLC method.…”
Section: Discussionmentioning
confidence: 99%
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