Hemostatic Effects of Bio-Zeolite Gauze and QuikClot Combat Gauze on Major Bleeding in Rabbits Acutely Exposed to High Altitude

Jia, Yijun; Du, Wenqiong; Zong, Zhaowen; Jiang, Renqing; Zhong, Xin; Ye, Zhao; Li, Tanshi; Yang, Haoyang; Xiao, Liping; Fan, Jie

doi:10.1080/10903127.2022.2126912

Cited by 4 publications

(2 citation statements)

References 31 publications

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“…3 For an ideal hemostatic material, it should show rapid hemostasis, easy operation, good biocompatibility and mechanical protection, and minimal tissue irritation, and so on. [4][5][6][7][8][9][10][11][12] Gauze is currently the most widely used topical hemostatic dressing in clinical practice that can effectively control massive bleeding, [13][14][15] because it is cost-effective, easily applicable, nonirritable, breathable, conformable, and highly hydrophilic. It can act as a very effective physical barrier to bleeding wounds.…”

Section: Introductionmentioning

confidence: 99%

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Modified cotton gauze with high hemostatic efficacy due to controllable hygroscopicity and wet tissue adhesiveness

Li,

Chen,

Huang

et al. 2024

J of Applied Polymer Sci

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In circumstances of severe traumatic bleeding, urgent bleeding control is vital to the wellness and life of the wounded person. Among many hemostatic measures, gauze is widely used because of cost‐effectiveness, safety and efficiency. However, it may suck a large amount of blood before bleeding stops. Thus, advanced hemostatic gauzes less blood loss and quick hemostatic rate and is greatly demanded. Herein, a novel tissue adhesive gauze (TA‐gauze) is developed by coating a thin layer of polyethyleneimine/poly(acrylic acid) (PEI/PAA) on the plain cotton gauze. This TA‐gauze has a reduced hydrophilicity and gets a new trait of wet tissue adhesiveness from the PEI/PAA coating layer. The TA‐gauze shows much improved hemostatic performance in the rat injury models, that is, its blood loss in the rat femoral artery model is just 13% that of the cotton gauze, due to it can retard the blood movement in the gauze and at the seam of gauze/tissue through a synergistic effect of tissue adhesion and hygroscopicity. It is biocompatible and on‐demand detachable. The simple preparation procedure and high hemostatic efficiency of the TA‐gauze may promise a bright future for an ideal hemostatic dressing for bleeding control.

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Section: Introductionmentioning

confidence: 99%

“…Gauze is currently the most widely used topical hemostatic dressing in clinical practice that can effectively control massive bleeding, 13–15 because it is cost‐effective, easily applicable, nonirritable, breathable, conformable, and highly hydrophilic. It can act as a very effective physical barrier to bleeding wounds 16,17 .…”

Section: Introductionmentioning

confidence: 99%

Modified cotton gauze with high hemostatic efficacy due to controllable hygroscopicity and wet tissue adhesiveness

Li,

Chen,

Huang

et al. 2024

J of Applied Polymer Sci

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Evolution of systemic and local hemostatic agents in armed conflicts

Gretsov,

Dmitriev,

Obedkov

et al. 2024

Pirogov Rus. J. Surg.

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Unsupervised neural network for single cell Multi-omics INTegration (UMINT): an application to health and disease

Maitra

Seal²,

Das

et al. 2023

Front. Mol. Biosci.

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Multi-omics studies have enabled us to understand the mechanistic drivers behind complex disease states and progressions, thereby providing novel and actionable biological insights into health status. However, integrating data from multiple modalities is challenging due to high dimensionality and diverse nature of data, and noise associated with each platform. Sparsity in data, non-overlapping features and technical batch effects make the task of learning more complicated. Conventional machine learning (ML) tools are not quite effective against such data integration hazards due to their simplistic nature with less capacity. In addition, existing methods for single cell multi-omics integration are computationally expensive. Therefore, in this work, we have introduced a novel Unsupervised neural network for single cell Multi-omics INTegration (UMINT). UMINT serves as a promising model for integrating variable number of single cell omics layers with high dimensions. It has a light-weight architecture with substantially reduced number of parameters. The proposed model is capable of learning a latent low-dimensional embedding that can extract useful features from the data facilitating further downstream analyses. UMINT has been applied to integrate healthy and disease CITE-seq (paired RNA and surface proteins) datasets including a rare disease Mucosa-Associated Lymphoid Tissue (MALT) tumor. It has been benchmarked against existing state-of-the-art methods for single cell multi-omics integration. Furthermore, UMINT is capable of integrating paired single cell gene expression and ATAC-seq (Transposase-Accessible Chromatin) assays as well.

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Hemostatic Effects of Bio-Zeolite Gauze and QuikClot Combat Gauze on Major Bleeding in Rabbits Acutely Exposed to High Altitude

Cited by 4 publications

References 31 publications

Modified cotton gauze with high hemostatic efficacy due to controllable hygroscopicity and wet tissue adhesiveness

Modified cotton gauze with high hemostatic efficacy due to controllable hygroscopicity and wet tissue adhesiveness

Evolution of systemic and local hemostatic agents in armed conflicts

Unsupervised neural network for single cell Multi-omics INTegration (UMINT): an application to health and disease

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