Hemostatic Factors and Replacement of Major Blood Loss with Plasma-Poor Red Cell Concentrates

Hiippala, Seppo; Myllylä, G.; Vahtera, Elina

doi:10.1213/00000539-199508000-00026

Cited by 210 publications

(283 citation statements)

References 13 publications

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“…3 A decrease in fibrinogen level is the first sign of impaired coagulation in haemorrhages. 4 Charbit et al recently published the first study comparing coagulation changes during the course of PPH according to the outcome. They showed that the level of fibrinogen during the first hour was the only parameter independently and significantly associated with the worsening of bleeding during PPH.…”

Section: Discussionmentioning

confidence: 99%

“…When bleeding occurs, the decrease in fibrinogen levels is the most rapid change observed among markers of coagulation. 4 Recent findings show that fibrinogen concentration during the initial management of PPH is the most informative biological marker for the severity of the haemorrhage 5 justifying early correction. Unfortunately, laboratory results are usually delayed making the early diagnosis and the management of hypofibrinogenemia difficult.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry

Huissoud

Carrabin

Audibert

et al. 2009

BJOG

207

161

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Objectives To establish whether reagent-supported thrombelastometry with the rotation thrombelastometry system (ROTEM Ò ) point-of-care device correlated with fibrinogen level in postpartum haemorrhages.Design Prospective observational study.Population and setting Ninety-one women at the third trimester of pregnancy: 37 with postpartum haemorrhage (study group) and 54 without abnormal bleeding (control group).Methods Standard laboratory test results were compared with those obtained at bedside from the ROTEM with the FIBTEM Ò test (54 tests in the control group and 51 in the study group). Results Median fibrinogen level was significantly lower in the haemorrhage group than in the control group (3.4 and 5.1 g/l, respectively, P < 0.0001). Median CT was higher in the haemorrhage group than in the control group (P = 0.05). CA 5 , CA 15 and MCF were significantly lower in the haemorrhage group than in controls (P < 0.0001) and strongly correlated with fibrinogen levels in both groups (r = 0.84-0.87, P < 0.0001). A cut-off value of CA 5 at 5 mm and CA 15 at 6 mm presented an excellent sensitivity (100% for both parameters) and a good specificity (respectively 85 and 88%) to detect fibrinogen levels <1.5 g/l in postpartum haemorrhage.Conclusions The early parameters obtained from the FIBTEM test correlated well with fibrinogen levels. ROTEM might be helpful in guiding fibrinogen transfusion during postpartum haemorrhage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry

Huissoud

Carrabin

Audibert

et al. 2009

BJOG

207

161

View full text Add to dashboard Cite

show abstract

“…In the present case, hypofibrinogenemia and lack of other factors for the clot formation cascade were promptly diagnosed by MCF < 7 mm in FIBTEM and managed by timely transfusion of cryoprecipitate. Fibrinogen is the first factor that is typically depleted during massive bleeding and hemodilution [13] and suggested to maintain 1.5-1.8 g/L [11,14]. Meanwhile, the conventional indirect Clauss method is not reliable to determine the fibrinogen level in the use of heparin as in the present case (Figure-2).…”

Section: Discussionmentioning

confidence: 73%

Rotational Thromboelastometry as a Routine Point-of-Care Test Immediately after Cardiopulmonary Bypass Facilitated Earlier Diagnosis of Unexpected Hyperfibrinolysis and Hypofibrinogenemia During Cardiac Surgery

Кwon¹,

Oh²,

Kang³

et al. 2016

Int J Surg Surgical Proced

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“…Fibrinogen is the fi rst coagulation factor to decrease below lower reference values during bleeding [31]. As the precursor to fi brin, and as a ligand for platelet aggregation, fi brinogen plays a key role in clot formation [32].…”

Section: Maintain Adequate Levels Of Coagulation Factorsmentioning

confidence: 99%

Point-of-Care Coagulation Management in Intensive Care Medicine

Meybohm¹,

Zacharowski²,

Weber³

2013

Annual Update in Intensive Care and Emergency Medicine 2013

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Hemostatic Factors and Replacement of Major Blood Loss with Plasma-Poor Red Cell Concentrates

Cited by 210 publications

References 13 publications

Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry

Bedside assessment of fibrinogen level in postpartum haemorrhage by thrombelastometry

Rotational Thromboelastometry as a Routine Point-of-Care Test Immediately after Cardiopulmonary Bypass Facilitated Earlier Diagnosis of Unexpected Hyperfibrinolysis and Hypofibrinogenemia During Cardiac Surgery

Point-of-Care Coagulation Management in Intensive Care Medicine

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