Hemostatic Self-Healing Hydrogel with Excellent Biocompatibility Composed of Polyphosphate-Conjugated Functional PNIPAM-Bearing Acylhydrazide

Abstract

Biocompatible self-healing hydrogels present an effective application as drug-releasing vehicles for tissue engineering and wound repairing. At the same time, the effective hemostatic property of the hydrogels also improves the application property as wound dressing materials. In this research, the PNIPAM-bearing acylhydrazide P(NIPAM-co-AH) was synthesized and then hemostatic polyphosphate (PolyP) was imported to prepare polyphosphate-conjugated P(NIPAM-co-AH) (PNAP). Through the acylhydrazone connection of PNAP and aldehyde functional PEO (PEO DA), the self-healing hydrogel with a hemostatic property was fabricated with good flexibility and sealing effect. The resultant hydrogels kept excellent biocompatibility and showed controlled drug release behavior. More importantly, the hydrogel accelerated the coagulation rate in vitro and presented a strong hemostatic effect as the binder in the hemorrhage model in vivo, which endow the hemostatic hydrogel with a very useful drug delivery carrier for wound healing applications or first aid treatment of the wounded in critical situations.

Versatile Bilayer Hydrogel for Wound Dressing through PET-RAFT Polymerization

“…One advantage of hydrogels is their tunable properties imparted by multifunctional groups or polymeric architectures. Indeed, a desirable wound dressing requires multiple properties including but not limited to excellent stretchability, bumping resistance, broad-spectrum antibacterial capability, and intelligent drug release. − However, it is almost impossible to reach a satisfactory balance between these properties simply by changing the polymeric network or imparting functional groups . At present, the performance of existing hydrogel dressing has many limitations.…”

“…marked by a pink circle). Furthermore, the thickness of the regenerated epidermis and the skin appendages indicates that H15 -PN 85 /PVA 40 -Pam 60 and H 20 -PN 80 /PVA 40 -PAm 60 hydrogels have significant effects on wound healing. These results indicate that the H 15 -PN 85 /PVA 40 -PAm 60 and H 20 -PN 80 / PVA 40 -PAm 60 hydrogel-treated groups are significant to cutaneous tissue remodeling and regeneration.Additionally, we monitored the degree of collagen deposition at the wound site by Masson staining the regenerated skins of the wound collected on the 7th and 15th days (Figure7D, blue representing collagen fiber).…”

Design of Adhesive Hemostatic Hydrogels Guided by the Interfacial Interactions with Tissue Surface

“…Visceral hemorrhage models of the heart, [22c,41c] liver, [ 13,104 ] spleen, [41a,61c] stomach, [56c,81,89a] and intestinal [ 58,66a ] bleeding models were employed to assess the hemostatic effectiveness of adhesive hemostatic hydrogels in acute bleeding situation. To evaluate the in vivo hemostatic and wound healing abilities of adhesive hemostatic hydrogels, sense organs injury models [27b,56b,105] were also developed. Skin tissue is most susceptible to external stimuli and harm because it is the outermost barrier of body.…”

Thermosensitive PNIPAM-Based Hydrogel Crosslinked by Composite Nanoparticles as Rapid Wound-Healing Dressings

“…So far, PNIPAM has been modified using varied biological modulators to achieve excellent biocompatibility and antibacterial and antioxidant properties. 16,17 In this paper, we address a novel efficient strategy to enhance the ROS scavenging activity of nano-CeO 2 called MSN-CeO 2 @PNIPAM thermoresponsive hydrogels (PMCTHs), which can dynamically turn into a gel from the liquid state at body temperature. In this system, nano-CeO 2 was loaded with mesoporous silica (MSN) with large specific surface area; 18 second, the synthetic MSN-CeO 2 was then encapsulated into PNIPAM through physical crosslinking to prepare MSN-CeO 2 @PNIPAM composite thermoresponsive hydrogels (PMCTHs).…”