This report describes a case of postoperative wound complication of the sternum after the transmanubrial osteomuscular sparing approach (TMA).The case was a 48-year-old man diagnosed with adenosquamous carcinoma of the right upper lobe of the lung. After induction chemoradiation therapy, right upper lobectomy with combined resection of the right brachiocephalic vein by TMA was performed. The sternum was closed using sternal wires. Postoperatively, he recovered well and was able to engage in manual labor. After 2 years and 9 months, he developed a wound infection and sternal osteomyelitis caused by breakage of the wires. We removed the wires and drained a subcutaneous abscess. Intraoperatively, two of the wires were found to have broken into three parts.The sternal wound after TMA tends to be unstable. Younger patients with high activity levels could develop complications related to the sternum after TMA. We need to identify issues of the sternum in patients with a history of surgery through TMA.