Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening

Grimberg, Brian T.; Grimberg, Kerry O.

doi:10.1080/14787210.2016.1222900

Cited by 16 publications

(8 citation statements)

References 36 publications

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“…The short laser pulse administered is skin-safe and the test is estimated to take only a few seconds to perform and is able to detect 0.00034% parasitemia (Table 2) [38]. Since hemozoin clears from the blood within nine days, compared to pHRP-2 which is cleared only after several months, this method is expected to produce few false-positive results [40].…”

Section: Transdermal Hemozoin Detectionmentioning

confidence: 99%

Evaluation of Malaria Diagnostic Methods as a Key for Successful Control and Elimination Programs

2020

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Malaria is one of the leading causes of death worldwide. According to the World Health Organization’s (WHO’s) world malaria report for 2018, there were 228 million cases and 405,000 deaths worldwide. This paper reviews and highlights the importance of accurate, sensitive and affordable diagnostic methods in the fight against malaria. The PubMed online database was used to search for publications that examined the different diagnostic tests for malaria. Currently used diagnostic methods include microscopy, rapid diagnostic tests (RDT), and polymerase chain reaction (PCR). Upcoming methods were identified as loop-mediated isothermal amplification (LAMP), nucleic acid sequence-based amplification (NASBA), isothermal thermophilic helicase-dependent amplification (tHDA), saliva-based test for nucleic-acid amplification, saliva-based test for Plasmodium protein detection, urine malaria test (UMT), and transdermal hemozoin detection. RDT, despite its increasing false negative, is still the most feasible diagnostic test because it is easy to use, fast, and does not need expensive equipment. Noninvasive tests that do not require a blood sample, but use saliva or urine, are some of the recent tests under development that have the potential to aid malaria control and elimination. Emerging resistance to anti-malaria drugs and to insecticides used against vectors continues to thwart progress in controlling malaria. Therefore, future innovation will be required to enable the application of more sensitive and affordable methods in resource-limited settings.

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Section: Transdermal Hemozoin Detectionmentioning

confidence: 99%

Evaluation of Malaria Diagnostic Methods as a Key for Successful Control and Elimination Programs

2020

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“…This structure resembles β-hematin, the synthetic hemozoin [ 32 , 33 ]. Although the hemozoin formation process is not entirely resolved, it is known that this crystal is optically birefringent and paramagnetic [ 34 , 35 , 36 , 37 , 38 ]. These unique features have become an attractive target for the development of new malaria detection methods [ 12 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Malaria Biomarkersmentioning

confidence: 99%

“…Although the hemozoin formation process is not entirely resolved, it is known that this crystal is optically birefringent and paramagnetic [ 34 , 35 , 36 , 37 , 38 ]. These unique features have become an attractive target for the development of new malaria detection methods [ 12 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ]. Among others, these include micro and miniaturized devices that have been explored for hemozoin-based malaria detection aiming to achieve portable, low-cost and low-power consumption detection [ 21 , 42 , 45 , 47 , 48 ].…”

Section: Malaria Biomarkersmentioning

confidence: 99%

Review of Microdevices for Hemozoin-Based Malaria Detection

et al. 2022

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Despite being preventable and treatable, malaria still puts almost half of the world’s population at risk. Thus, prompt, accurate and sensitive malaria diagnosis is crucial for disease control and elimination. Optical microscopy and immuno-rapid tests are the standard malaria diagnostic methods in the field. However, these are time-consuming and fail to detect low-level parasitemia. Biosensors and lab-on-a-chip devices, as reported to different applications, usually offer high sensitivity, specificity, and ease of use at the point of care. Thus, these can be explored as an alternative for malaria diagnosis. Alongside malaria infection inside the human red blood cells, parasites consume host hemoglobin generating the hemozoin crystal as a by-product. Hemozoin is produced in all parasite species either in symptomatic and asymptomatic individuals. Furthermore, hemozoin crystals are produced as the parasites invade the red blood cells and their content relates to disease progression. Hemozoin is, therefore, a unique indicator of infection, being used as a malaria biomarker. Herein, the so-far developed biosensors and lab-on-a-chip devices aiming for malaria detection by targeting hemozoin as a biomarker are reviewed and discussed to fulfil all the medical demands for malaria management towards elimination.

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“…This is a robust mobile diagnostic solution for malaria that have shown 94.4 per cent accuracy rate when applied to imagining blood samples provided by different labs. Briefly, Lifelens has replaced conventional way of malaria testing which were earlier done by unreliable cotton swab with a new approach with highdefinition, high-magnification camera (magnification upto 350 times), supported with better image analysis software to advance the precision diagnosis 49 . A drop of blood as sample drawn from person and placed on slide, later digitally examined through the lens with the use of attachment for higher magnification and resolution.…”

Section: Internet Of Diagnostic Thingsmentioning

confidence: 99%

Internet of Diagnostic Things: Emerging Horizon towards Precision and Digital Health Care

Verma¹,

Mishra

Bisht

et al. 2021

J Health Sci Res

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Digital revolution and advancement of information technologies, smart phone industry, multi-omic technologies, availability with 5G networks and emergence of big data era has greatly impacted on diagnostic, biomedical and e-healthcare sectors. Intelligent sensors, wearable, digital imaging, smart phone based diagnostic and connected networking provides smart approach and platform towards precision diagnostics. Recently, Internet of Things (IoT) have shown remarkable impact on diverge sectors such as digital imaging, smart sensing, digital diagnostic, digital biotech, telemedicine, precision farming, lab-on phone, smart home, smart city planning, smart retails and Research and Development (R&D) automation etc. Application of IoT technology in diagnostic and healthcare opens a way for personalization in the medical care depending on individual needs, additionally giving option for well-organized way for remote healthcare and management. This review focuses on theoretical, technological, advanced aspects of digital diagnostic utilizing IoT technology. Furthermore, we have also highlighted the opportunities and challenges for IoT in exploring the futuristic scope and innovation in diagnostic application. IoT based diagnostic, sensing and imaging devices provides unprecedented precision, automation in the diagnostic and thereby could significantly improve the biomedical and e-healthcare area.

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Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening

Cited by 16 publications

References 36 publications

Evaluation of Malaria Diagnostic Methods as a Key for Successful Control and Elimination Programs

Evaluation of Malaria Diagnostic Methods as a Key for Successful Control and Elimination Programs

Review of Microdevices for Hemozoin-Based Malaria Detection

Internet of Diagnostic Things: Emerging Horizon towards Precision and Digital Health Care

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