Industrial hemp is a multipurpose crop cultivated for fiber, seed, human food, and animal feed. Hemp legalization in Texas creates a considerable potential to increase its acreage in semi-arid conditions; however, knowledge to grow hemp optimally in Texas is limited. Best management practices, including weed control, need to be evaluated for profitable hemp production. Since little is known about the herbicide tolerance of hemp, field studies were conducted to test several soil-residual herbicides with different modes of action for phytotoxicity to two hemp cultivars, Yuma and Jinma. The experimental units were randomized three times in a blocked split-plot design with hemp cultivars in the main plots and soil-residual herbicides in the subplots. Ethalfluralin, the mixture of sulfentrazone and S-metolachlor, prometryn, and S-metolachlor, resulted in 60 to 90% and 73 to 100% weed control as compared to nontreated control in 2021 and 2022, respectively. The highest hemp germination, stand count, and plant height were observed with ethalfluralin and S-metolachlor herbicides; however, no significant differences were observed for hemp germination and plant height compared to nontreated control. S-metolachlor, ethalfluralin, fomesafen, and prometryn resulted in similar hemp biomass compared to the nontreated control. Overall, the results indicate that hemp is tolerant to ethalfluralin, prometryn, and S-metolachlor, and these soil-residual herbicides were effective for weed control in hemp. The mixture of bicyclopyrone and S-metolachlor, metribuzin and S-metolachlor, and mesotrione should be avoided due to significant injury to hemp plants. Future research is needed to test the efficacy of different preemergence and postemergence herbicides that can be used in industrial hemp grown under different environments, making sure the delta-9-tetrahydrocannabinol (THC) content of the hemp is below the legal content restrictions.