The COVID-19 Pandemic has forced healthcare professionals worldwide to make and implement decisions under extreme pressure, which is naturally a source of stress and anxiety for all healthcare professionals. This study examined the mediating role of task-related occupational anxiety in the relationship between nurses’ stress-coping behaviours and crisis management skills. The sample consists of nurses working in the Eastern Anatolia Region. Because the research was conducted within the scope of COVID-19 epidemic measures, the questionnaire was online, and 400 electronic questionnaires were analysed. According to the results obtained in the research, significant relationships were found between stress-coping behaviours, crisis management skills and task-related occupational anxiety, as well as between task-related occupational anxiety and crisis management skills. In addition, it has been determined that task-related occupational anxiety mediates the relationship between stress-coping behaviours and crisis management skills. The results are discussed in the axis of the research results in the related literature.