2014
DOI: 10.3201/eid2003.131159
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Hendra Virus Vaccine, a One Health Approach to Protecting Horse, Human, and Environmental Health

Abstract: In recent years, the emergence of several highly pathogenic zoonotic diseases in humans has led to a renewed emphasis on the interconnectedness of human, animal, and environmental health, otherwise known as One Health. For example, Hendra virus (HeV), a zoonotic paramyxovirus, was discovered in 1994, and since then, infections have occurred in 7 humans, each of whom had a strong epidemiologic link to similarly affected horses. As a consequence of these outbreaks, eradication of bat populations was discussed, d… Show more

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Cited by 177 publications
(184 citation statements)
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“…Realising that the eradication of flying foxes would be an almost impossible challenge with unpredictable consequences (Middleton et al, 2014;Plowright et al, 2011) -and morally questionable besides -organised responses to the threats posed by HeV have concentrated on three areas:…”
Section: Of Hendra Horses and Public Ordermentioning
confidence: 99%
See 1 more Smart Citation
“…Realising that the eradication of flying foxes would be an almost impossible challenge with unpredictable consequences (Middleton et al, 2014;Plowright et al, 2011) -and morally questionable besides -organised responses to the threats posed by HeV have concentrated on three areas:…”
Section: Of Hendra Horses and Public Ordermentioning
confidence: 99%
“…In the third response to the emergence of HeV, the intent of developing a vaccine for horses was to break the chain of transmission from flying foxes to horses to humans, thereby protecting horse and human health (Middleton et al, 2014). This intervention was perceived to be the most direct means of achieving the desired health protection outcomes, while also allowing equine industries to continue in affected areas.…”
Section: Of Hendra Horses and Public Ordermentioning
confidence: 99%
“…Despite the recent availability of a commercial vaccine for horses, spillover events continue to occur. Many at-risk horses remain unvaccinated due to the cost of the vaccine, risk perceptions of horse owners and other factors (Middleton et al, 2014). Undertaking more cost-effective alternative mitigation strategies is constrained by a lack of implementation of the management recommendations.…”
Section: Introductionmentioning
confidence: 99%
“…A candidate vaccine based on the antigen HeVsG was first efficacy tested in cats against Nipah virus (30, 31) and subsequently in ferrets against HeV (32), and the success of the outcomes to virus exposure in these species encouraged translation of the work into the horse (33). For use in the horse, sG was specifically reformulated with a proprietary adjuvant approved for use in that species and delivered as an inactivated subunit vaccine.…”
Section: A Hendra Virus Vaccine For Horsesmentioning
confidence: 99%