A series of life test measurements has been performed in He-Ne gas laser discharges using several different types of laser discharge cells. These studies have explored the mechanisms that lead to the failure of the discharges in these cells. Specifically, the dependence of the life of the discharge on the operating parameters (discharge current, cell temperature, gas composition and total and partial gas pressures) and on the materials used to construct the cathodes and discharge cells have been studied. The gas removal rates for He and Ne have been found to be very different from each other, and to depend on the operating conditions and cell construction materials. Positive ion-molecule reaction studies have been performed in a separate drift-tube-mass-spectrometer system in which the mechanisms leading to molecular impurity gas clean-up in these He-Ne discharges have been explored.