Henoch Schonlein Purpura in Childhood: Epidemiological and Clinical Analysis of 150 Cases Over a 5-year Period and Review of Literature

Trapani, Sandra; Micheli, Annalisa; Grisolia, Francesca; Resti, Massimo; Chiappini, Elena; Falcini, Fabio; Martino, Maurizio de

doi:10.1016/j.semarthrit.2005.08.007

Cited by 402 publications

(441 citation statements)

References 72 publications

Supporting

Mentioning

312

Contrasting

Unclassified

Order By: Relevance

“…As expected these patients were significantly younger than the UNOS population as a whole, which is consistent with prior reports that the annual incidence of HSP in adults is only one-tenth of that observed in children (1). Prior studies have reported a gender difference in primary HSP, with a 2:1 ratio of men to women; however, we did not find a significant preponderance of men in the HSP transplant population in the UNOS database (53% men) (13). The HSP patients in the UNOS database were predominately Caucasian, with significantly fewer African Americans than the database as a whole.…”

Section: Discussionsupporting

confidence: 91%

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

Samuel¹,

Bell²,

Molony³

et al. 2011

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

SummaryBackground and objectives Although Henoch-Schö nlein purpura (HSP) is the most common form of renal vasculitis in childhood, progression to ESRD is rare, and there are few data on outcomes of renal transplantation in patients with HSP.Design, setting, participants, & measurements This is a matched retrospective cohort study of renal allografts using the United Network of Organ Sharing database (1987 to 2005). Of the 189,211 primary renal allografts, there were 339 with a diagnosis of HSP. The primary end point was allograft survival. ResultsCompared with the remainder of the database, the HSP population was younger (25 years versus 46 years), and had a higher proportion of women (47% versus 40%), live donors (50% versus 35%), and Caucasians (77% versus 60%). Controlling for age, gender, donor source, ethnicity, and year of transplantation, death-censored graft survival for patients with HSP was 80.0% at 5 years and 58.8% at 10 years compared with 79.0% at 5 years and 55.4% at 10 years in the non-HSP population. Among patients with reported causes of graft loss, failure from recurrent disease occurred in 13.6% of patients with HSP, compared with 6.6% in the non-HSP population. When analyzing allograft survival in recipients with HSP compared with those with IgA nephropathy, there was no difference in 10-year allograft survival (58.4% and 59.3%, respectively). ConclusionsThese data indicate that although there is an increased risk of graft failure attributable to recurrent disease in patients with HSP, a diagnosis of HSP has little effect on overall renal allograft survival.

show abstract

Section: Discussionsupporting

confidence: 91%

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

Samuel¹,

Bell²,

Molony³

et al. 2011

Clinical Journal of the American Society of Nephrology

View full text Add to dashboard Cite

show abstract

“…Surgical complications are rare in adults and children under the age of three. The most common surgical complication in patients with gastrointestinal involvement is invagination, and its incidence is known to be less than 1% [3,4,[22][23][24]. In our study, three patients have been operated due to invagination (0.04%).…”

Section: Discussionmentioning

confidence: 70%

Tooth fragments embedded in the lower lip following trauma

Benzer¹,

Duramaz²,

Önal³

et al. 2015

MMJ

View full text Add to dashboard Cite

Objectives: Henoch-Schönlein purpura (HSP) or IgA vasculitis, is the most common form of childhood vasculitis. Mean platelet volume (MPV) is a parameter of a complete blood count that shows thrombocyte function and activation. This study evaluated the link between MPV and HSP. Patients and Methods:The data of 75 patients with a diagnosis of HSP were retrospectively evaluated. A control group was formed with 79 healthy children of similar gender and ages. results:The average ages were 6.8±3.02 years (44 males, 31 females) and 7.49±2.95 years (40 males, 39 females) for the patient and control groups respectively. Mean platelet volume was found to be significantly lower in the study group (p<0.0001). Patients' thrombocyte count were significantly higher (p<0.0001). Upon presentation 18 patients' faecal occult blood (FOB) test results were positive, and there was microscopic hematuria in 12 patients, MPV was found to be significantly lower in FOB positive patients (p=0.043).conclusion: Inflammation may affect MPV levels by increasing or decreasing. In our study, MPV measurements performed by a cheap and simple method, have been considered as a negative acute phase reactant. Decreased MPV measurements despite increased platelet count may be important in the prediction of hypercoagulopathy problems during the likely course of the disease and in close follow up for those with a predisposition. Ortalama trombosit hacmi çalışma grubunda anlamlı derecede düşük saptandı (p<0,0001). Hastaların trombosit sayısı anlamlı derecede yüksek bulundu (p<0,0001). Başvuru anında 18 hastada gizli gaite kan (GGK) testi pozitifti ve 12 hastada mikroskopik hematüri mevcuttu, GGK pozitif olan hastalarda OTH anlamlı düşük bulundu (p=0,043). sonuç: İnflamasyon, OTH düzeyini artma/azalma şeklinde etkileyebilmektedir. Çalışmamızda ucuz ve basit bir yöntem olan OTH ölçümleri negatif akut faz reaktanı olarak değerlendirilmiştir. Henoch-Schönlein purpuralı çocuklarda, artmış trombosit sayısına karşın, azalmış OTH ölçümlerinin, yatkınlığı olanlarda, hastalık seyrindeki olası hiperkoagülopati problemlerinin önceden belirlenmesinde ve yakın takipte önemli olabileceği kanısına varılmıştır.

show abstract

“…The major manifestations are purpura, arthritis, gastrointestinal bleeding, and nephritis [3,4]. Nephritis rarely if ever precedes the onset of purpura in HSP, in fact, the onset of nephritis may be delayed for weeks or months after the appearance of other symptoms [2,3,[5][6][7].…”

Section: Discussionmentioning

confidence: 99%

“…Given those close pathological and clinical associations of IgAN and HSPN, some researchers surmise that IgAN and HSP are different clinical manifestations of the same disease, sharing a common pathogenesis [2,12,13]. Although it is said that nephritis rarely precede the onset of purpura in HSP [2,3,[5][6][7], HSP without any extra-renal involvements can never be diagnosed HSP but IgAN by pathological and clinical findings at the time of diagnosis. CRP titer was positive when first diagnosis of IgAN had been made, while IgAN is usually not accompanied by CRP elevation.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary hemorrhage associated with Henoch-Schöenlein purpura in an adult patient primary diagnosed of IgA nephropathy

et al. 2014

View full text Add to dashboard Cite

We describe a case of IgA nephropathy (IgAN) followed by pulmonary hemorrhage associated with Henoch-Schöenlein purpura (HSP) in an adult female. The patient had a history of renal insufficiency and persistent hematuria and proteinuria, without any extra-renal involvement. She was diagnosed with IgAN 7 years before the onset of HSP and had received immunosuppressive therapy for 6 years. One year after discontinuing oral prednisolone and mizoribine, she suffered a pulmonary hemorrhage. She presented with exacerbated urinary findings, and palpable purpura, resulting in the diagnosis of HSP. Intravenous pulse methylprednisolone followed by oral prednisolone (1 mg/kg/day) and a monthly intravenous cyclophosphamide pulse resolved the pulmonary hemorrhage. In a review of 36 HSP patients complicated with pulmonary hemorrhage, 27.8 % of the patients perished [Rajagopala et al.,1]. While the most efficient therapeutic strategies for these patients have yet to be determined, we speculate that an aggressive therapy of pulse methylprednisolone combined with immunosuppression agents is likely to bring about the best outcome in cases with pathological conditions similar to our patient's. On the other hand, discontinuance of immunosuppressive therapy might have resulted in the aggravation of the disease, hence we should examine patients carefully not to miss the cue.

show abstract

Henoch Schonlein Purpura in Childhood: Epidemiological and Clinical Analysis of 150 Cases Over a 5-year Period and Review of Literature

Cited by 402 publications

References 72 publications

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

Long-term Outcome of Renal Transplantation Patients with Henoch-Schönlein Purpura

Tooth fragments embedded in the lower lip following trauma

Pulmonary hemorrhage associated with Henoch-Schöenlein purpura in an adult patient primary diagnosed of IgA nephropathy

Contact Info

Product

Resources

About