2023
DOI: 10.3390/vetsci10120668
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Hepadnavirus Infection in a Cat with Chronic Liver Disease: A Multi-Disciplinary Diagnostic Approach

Paolo Capozza,
Francesco Pellegrini,
Michele Camero
et al.

Abstract: A 3-year-old female stray, shorthair cat, with clinical signs and serum chemistry markers indicative of hepatic disease, was diagnosed with domestic cat hepadnavirus (DCH) infection. Coupling molecular and serological data, the infection was seemingly contextualized into a chronic phase, since IgM anti-core antibodies, a marker of early-stage Hepatitis B Virus (HBV) infection, were not detected. However, the cat possessed IgG anti-core, a common indicator of chronic HBV infection in human patients and did not … Show more

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Cited by 4 publications
(2 citation statements)
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“…Detection of DCH DNA confirms infection, but a negative qPCR result does not rule out infection since not all infected cats are expected to be viraemic [ 47 ]. Progress has been made towards developing a panel of markers that will help to clarify the threat that DCH poses to feline health, as well as its natural history and global epidemiology [ 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…Detection of DCH DNA confirms infection, but a negative qPCR result does not rule out infection since not all infected cats are expected to be viraemic [ 47 ]. Progress has been made towards developing a panel of markers that will help to clarify the threat that DCH poses to feline health, as well as its natural history and global epidemiology [ 48 ].…”
Section: Discussionmentioning
confidence: 99%
“…The hybridization signals were prominently observed in lymphoma tissues, with no reaction observed in the negative control section. Furthermore, we conducted immunohistochemistry (IHC) to detect DCH protein using anti-HBV core antigen (HBcAg), a method that has shown cross-reactivity with DCH core protein in previous studies [4,24] and has been employed to ascertain DCH infection [24,26]. Finally, we express sincere appreciation for the insightful commentary on our peerreviewed study entitled "Domestic cat hepadavirus antigen in lymphoma tissues".…”
mentioning
confidence: 99%