Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma

Si, Jinchao; Li, Wei; Li, Xin; Cao, Lixing; Chen, Zhiqiang; Zao, Jiang

doi:10.1111/cas.14984

Cited by 33 publications

(34 citation statements)

References 42 publications

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“…Over the last decade, circRNAs have been reported as important mediators related to the development of chemoresistance in various tumors, such as gastric cancer [ 172 , 173 ], non-small-cell lung cancer [ 174 ], esophageal cancer [ 175 ], pancreatic cancer [ 176 , 177 ], colorectal cancer [ 152 – 154 , 178 ], glioma [ 179 , 180 ], and osteosarcoma [ 181 , 182 ]. However, there are few studies on exosomal circRNA drug resistance to tumors, and the mechanism remains unknown.…”

Section: Main Textmentioning

confidence: 99%

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

et al. 2022

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Colorectal cancer (CRC) is one of the most common cancers worldwide and a leading cause of carcinogenic death. To date, surgical resection is regarded as the gold standard by the operator for clinical decisions. Because conventional tissue biopsy is invasive and only a small sample can sometimes be obtained, it is unable to represent the heterogeneity of tumor or dynamically monitor tumor progression. Therefore, there is an urgent need to find a new minimally invasive or noninvasive diagnostic strategy to detect CRC at an early stage and monitor CRC recurrence. Over the past years, a new diagnostic concept called “liquid biopsy” has gained much attention. Liquid biopsy is noninvasive, allowing repeated analysis and real-time monitoring of tumor recurrence, metastasis or therapeutic responses. With the advanced development of new molecular techniques in CRC, circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), exosomes, and tumor-educated platelet (TEP) detection have achieved interesting and inspiring results as the most prominent liquid biopsy markers. In this review, we focused on some clinical applications of CTCs, ctDNA, exosomes and TEPs and discuss promising future applications to solve unmet clinical needs in CRC patients.

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Section: Main Textmentioning

confidence: 99%

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

et al. 2022

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“…Here, we summarized the contribution of circRNAs to chemoresistance in glioma patients ( Table 5 ). It has been shown that exosomal hsa_circ_0042003, mediated by heparanase transfers from temozolomide (TMZ)-resistant glioma cells to drug-sensitive cells, which contributes to TMZ resistance in glioma ( 113 ). In glioma, exosomal circ_0072083 modulates NANOG and ALKBH5 by targeting miR-1252-5p and demethylation to control TMZ resistance ( 114 ).…”

Section: Circrnas and Drug Resistancementioning

confidence: 99%

The Role of Circular RNAs in the Drug Resistance of Cancers

et al. 2022

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Cancer is a major threat to human health and longevity. Chemotherapy is an effective approach to inhibit cancer cell proliferation, but a growing number of cancer patients are prone to develop resistance to various chemotherapeutics, including platinum, paclitaxel, adriamycin, and 5-fluorouracil, among others. Significant progress has been made in the research and development of chemotherapeutic drugs over the last few decades, including targeted therapy drugs and immune checkpoint inhibitors; however, drug resistance still severely limits the application and efficacy of these drugs in cancer treatment. Recently, emerging studies have emphasized the role of circular RNAs (circRNAs) in the proliferation, migration, invasion, and especially chemoresistance of cancer cells by regulating the expression of related miRNAs and targeted genes. In this review, we comprehensively summarized the potential roles and mechanisms of circRNAs in cancer drug resistance including the efflux of drugs, apoptosis, intervention with the TME (tumor microenvironment), autophagy, and dysfunction of DNA damage repair, among others. Furthermore, we highlighted the potential value of circRNAs as new therapeutic targets and prognostic biomarkers for cancer.

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“…It has been demonstrated to reduce the sensitivity of gliomas to TMZ ( 146 ). Exosomes derived from TMZ-resistant glioma cells mediate the transfer of chemoresistance to TMZ-sensitive glioma cells via circ_0042003 ( 147 ). Therefore, exosomal circRNAs have an undeniable role in TMZ resistance.…”

Section: Circrnas and Drug Resistance Of Gliomasmentioning

confidence: 99%

NcRNAs: Multi‑angle participation in the regulation of glioma chemotherapy resistance (Review)

et al. 2022

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As the most common primary tumour of the central nervous system, gliomas have a high recurrence rate after surgical resection and are resistant to chemotherapy, particularly high-grade gliomas dominated by glioblastoma multiforme (GBM). The prognosis of GBM remains poor despite improvements in treatment modalities, posing a serious threat to human health. At present, although drugs such as temozolomide, cisplatin and bevacizumab, are effective in improving the overall survival of patients with GBM, most patients eventually develop drug resistance, leading to poor clinical prognosis. The development of multidrug resistance has therefore become a major obstacle to improving the effectiveness of chemotherapy for GBM. The ability to fully understand the underlying mechanisms of chemotherapy resistance and to develop novel therapeutic targets to overcome resistance is critical to improving the prognosis of patients with GBM. Of note, growing evidence indicates that a large number of abnormally expressed noncoding RNAs (ncRNAs) have a central role in glioma chemoresistance and may target various mechanisms to modulate chemosensitivity. In the present review, the roles and molecular mechanisms of ncRNAs in glioma drug resistance were systematically summarized, the potential of ncRNAs as drug resistance markers and novel therapeutic targets of glioma were discussed and prospects for glioma treatment were outlined. ncRNAs are a research direction for tumor drug resistance mechanisms and targeted therapies, which not only provides novel perspectives for reversing glioma drug resistance but may also promote the development of precision medicine for clinical diagnosis and treatment.

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Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma

Cited by 33 publications

References 42 publications

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

Liquid biopsy at the frontier of detection, prognosis and progression monitoring in colorectal cancer

The Role of Circular RNAs in the Drug Resistance of Cancers

NcRNAs: Multi‑angle participation in the regulation of glioma chemotherapy resistance (Review)

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