Heparin Administration Appears to Decrease Cellular Binding of Thyroxine

Schwartz, Harold L.; Schadlow, Alan R.; Faierman, Daniel; Surks, Martin I.; Oppenheimer, Jack H.

doi:10.1210/jcem-36-3-598

Cited by 32 publications

(9 citation statements)

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“…Recently, several reports appeared on the action of diphenylhydantoin (Larsen et al 1970), heparin (Schwartz et al 1973), salicylate (Larsen 1972), barbiturates (Michajlovskij 8c Knopp 1973), univalent anions (Michajlovskip 8c Langer 1974) and other compounds (reviewed by Oppenheimer 1973) on various changes in the peripheral meta¬ bolism of thyroid hormones in vivo and thus numerous preceding studies in vitro by several investigators were confirmed. In these experiments and also in some unpublished studies, however, we failed to demonstrate any effect of heparin on T4 disappearance rate from plasma.…”

Section: Discussionmentioning

confidence: 95%

Acute Redistribution of Thyroxine After the Administration of Univalent Anions, Salicylate, Theophylline and Barbiturates in Rats

Langer

Kokesová

Gschwendtová

1976

Acta Endocrinologica

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Rats were injected with [125I]L-thyroxine (T4) ip 16 h before the experiment and samples of blood were frequently taken from polyethylene tubing inserted into the femoral artery in anaesthetized and heparin injected animals, isovolaemia being maintained. In each sample of plasma T4 counts per ml were estimated with the aid of paper chromatography. Rapid decrease of circulating T4 level was found at 20 min after iv injection of various compounds (thiocyanate, iodide, fluoroborate, theophylline and salicylate) and a dose-response relationship was established between such a decrease and the administered dose of salicylate (5\p=n-\160 mg/400 g b. w.). A similar decrease was observed at 60 min after ip injection of some general anaesthetics (thio-, pento-and allo-barbiturate, urethane) or tranquilizers (Innovar-Vet\s=r\).Finally, an increase of T4 fractional disposal rate was found between 120 and 480 min after the administration of some of the above mentioned anaesthetics and this effect was abolished by the administration of thiocyanate. It was concluded that there are two different effects of drugs on the circulating T4 level: 1. the immediate effect resulting apparently from a decreased plasma protein binding; 2. the prolonged effect which presumably results from the increased turnover of T4 by peripheral tissues, the metabolic basis of which remains unexplained.

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Section: Discussionmentioning

confidence: 95%

Acute Redistribution of Thyroxine After the Administration of Univalent Anions, Salicylate, Theophylline and Barbiturates in Rats

Langer

Kokesová

Gschwendtová

1976

Acta Endocrinologica

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“…The study population consisted of 16 (11,12), dilantin (13), or heparin (14,15) were excluded as were patients with known or suspected hypothalamic or pituitary disease, head trauma (16), thyroid disease, or recent thyroid (17) or glucocorticoid hormone therapies (18,19 Table II.…”

Section: Methodsmentioning

confidence: 99%

Peripheral Serum Thyroxine, Triiodothyronine and Reverse Triiodothyronine Kinetics in the Low Thyroxine State of Acute Nonthyroidal Illnesses

Kaptein¹,

Robinson²,

Grieb³

et al. 1982

J. Clin. Invest.

183

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A B S T R A C T The low thyroxine (T4) state of acute critical nonthyroidal illnesses is characterized by marked decreases in serum total T4 and triiodothyronine (T3) with elevated reverse T3 (rT3) values. To better define the mechanisms responsible for these alterations, serum kinetic disappearance studies of labeled T4, T3, or rT3 were determined in 16 patients with the low T4 state and compared with 27 euthyroid controls and a single subject with near absence of thyroxine-binding globulin. Marked increases in the serum free fractions of T4 (0.070±0.007%, normal [nl] 0.0315±0.0014, P <0.001), T3 (0.696±0.065%, nl 0.310±0.034, P <0.001), and rT3 (0.404±0.051%, nl 0.133±0.007, P < 0.001) by equilibrium dialysis were observed indicating impaired serum binding. Noncompartmental analysis of the kinetic data revealed an increased metabolic clearance rate (MCR) of T4 (1.69±0.22 liter/d per m2, nl 0.73±0.05, P < 0.001) and fractional catabolic rate (FCR) (32.8±2.6%, nl 12.0±0.8, P < 0.001), analogous to the euthyroid subject with low thyroxine-binding globulin. However, the reduced rate of T4 exit from the serum (Kii) (15.2±4.6 d-1, nl 28.4±3.9, P < 0.001) indicated an impairment of extravascular T4 binding that exceeded the serum binding defect. This defect did not apparThis work was presented in part at the 6th International Congress of Endocrinology, Melbourne, Australia, February, 1980 (Abstract No. 364), and at the 61st Annual Endocrine Society Meeting, Wash., D. C., June, 1980 These alterations in thyroid hormones indices and kinetic parameters for T4, T3, and rT3 in the low T4 state of acute nonthyroidal illnesses can be accounted for by: (a) decreased binding of T4, T3, and rT3 to vascular and extravascular sites with a proportionately greater impairment of extravascular T4 binding, and (b) impaired 5'-deiodination activity affecting both T4 and rT3 metabolism.

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“…Moreover, the same compounds may also increase the T4 disposal rate [Schwartz et al, 1973;Langer et al, 1976a]. Such effects were possibly involved in these experiments and further changes of free T4 fraction presumably resulted from the removal of specific rat T4 binding proteins by IET and their replacement by heterogenous bovine serum albumin.…”

Section: Discussionmentioning

confidence: 87%

Acute Decrease of Blood Thyroid Hormone by Isovolemic Exchange Transfusion as a Stimulus for Pulse TSH Release and Its Modifications by CNS Lesions

et al. 1977

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The level of thyroid hormone in blood has been acutely decreased by about 20-30% within 20 min with the aid of isovolemic exchange transfusion (IET) of thyroid hormone free blood cell suspension (THFBCS) in three groups of rats: (1) intact control (C); (2) median eminence (ME)-lesioned; (3) thalamus (TH)-lesioned. The levels of thyroxine (T₄) and TSH were measured by specific radioimmunoassay (RIA) before the transfusion and for 180 min after that. The level of T₄ increased to the initial value at about 120 min after IET in C and ME-lesioned rats, while in TH it remained decreased until 180 min. Furthermore, at the end of IET the level of TSH in C and ME-lesioned rats was about 2–3 times higher than the initial value and its continuous decrease was observed until 180 min. In contrast, in TH-lesioned rats the increase of TSH level was delayed, being significant at 60 min only. It was concluded that IET of THFBCS acts as a stimulus of acute TSH release which was remarkably inhibited in TH-lesioned animals. In addition, the destruction of most of the ME did not apparently influence this response, as shown by essentially similar data obtained in C and ME-lesioned rats.

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Heparin Administration Appears to Decrease Cellular Binding of Thyroxine

Cited by 32 publications

References 0 publications

Acute Redistribution of Thyroxine After the Administration of Univalent Anions, Salicylate, Theophylline and Barbiturates in Rats

Acute Redistribution of Thyroxine After the Administration of Univalent Anions, Salicylate, Theophylline and Barbiturates in Rats

Peripheral Serum Thyroxine, Triiodothyronine and Reverse Triiodothyronine Kinetics in the Low Thyroxine State of Acute Nonthyroidal Illnesses

Acute Decrease of Blood Thyroid Hormone by Isovolemic Exchange Transfusion as a Stimulus for Pulse TSH Release and Its Modifications by CNS Lesions

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