Heparin-binding epidermal growth factor–like growth factor decreases the incidence of necrotizing enterocolitis in neonatal rats

Feng, Jiexiong; El-Assal, Osama N.; Besner, Gail E.

doi:10.1016/j.jpedsurg.2005.10.018

Cited by 101 publications

(88 citation statements)

References 19 publications

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“…[15][16][17] HB-EGF is found in biologically significant quantities in breast milk and [15][16][17] found that treatment with HB-EGF resulted in reduced apoptosis, increased proliferation and migration, as well as maintenance of the epithelial barrier and mucosal integrity compared with control animals. The reduction of HB-EGF in pasteurized milk may have negative implications on the intestinal integrity of preterm infants, compared with MOM.…”

Section: Discussionmentioning

confidence: 99%

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Effect of pasteurization on selected immune components of donated human breast milk

et al. 2011

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Objective: Pasteurized, donated milk is increasingly provided to preterm infants in the absence of mother's own milk. The aim of this study was to determine the effect of pasteurization on the concentration of selected components in donated human breast milk.Study Design: Donated milk from 34 mothers was pooled into 17 distinct batches (4 mothers per batch). Aliquots of each batch were then Holder pasteurized (62.5 1C for 30 min). Interferon-g (IFN-g), tumor necrosis factor-a (TNF-a), interleukin-1b (IL-1b), IL-2, IL-4, IL-5, IL-8, IL-10, IL-12p70 and IL-13 were measured in a multiplex enzyme-linked immunosorbent assay (ELISA). Granulocyte colony-stimulating factor (G-CSF), heparin-binding epidermal-like growth factor (HB-EGF) and hepatocyte growth factor (HGF) were measured by ELISA. Lipids were assessed by gas chromatography and gangliosides by the resorcinol-HCl reaction.Result: IFN-g, TNF-a, IL-1b, IL-10 and HGF were significantly reduced by pasteurization (P<0.05). Gangliosides were not affected, but the proportion of medium-chain saturated fats was increased (P<0.05) with a trend towards a decreased proportion of oleic acid (P ¼ 0.057). Conclusion:Pasteurization significantly reduced the concentration of several immunoactive compounds present in breast milk, but did not have an impact on others.

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Section: Discussionmentioning

confidence: 99%

“…In a series of experiments using a neonatal rat model of NEC, Feng et al [15][16][17] determined that treatment with HB-EGF resulted in reduced apoptosis, increased proliferation and migration, as well as maintenance of the epithelial barrier and mucosal integrity compared with control animals.…”

Section: Introductionmentioning

confidence: 99%

Effect of pasteurization on selected immune components of donated human breast milk

et al. 2011

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“…Heparin-binding epidermal growth factor (HB-EGF) has similar effects (26) and has been shown to reduce inflammation in a rat model (27). Trials to test EGF and HB-EGF in premature infants at risk of NEC are planned, if problems can be overcome in regards to obtaining EGF and HB-EGF suitable for administration to preterm infants.…”

Section: Session Iii: Prevention and Treatmentmentioning

confidence: 99%

New Therapies and Preventive Approaches for Necrotizing Enterocolitis: Report of a Research Planning Workshop

et al. 2007

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“…(HB-EGF), [20][21][22] EGF, 23 other enteral growth factors 24,25 or probiotics 26,27 could be administered to term neonates that require NICU admission, using a randomized, placebo-controlled and masked design. Alternatively, if human milk was postulated to be protective, studies that randomized bottle-fed infants to banked human milk vs formula could be tested.…”

Section: Nec In Term Infantsmentioning

confidence: 99%

Necrotizing enterocolitis in term neonates: data from a multihospital health-care system

et al. 2007

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Objective: In the past 5½ years, 30 term or near-term neonates in the Intermountain Healthcare system developed necrotizing enterocolitis (NEC) Bell's stage XII. We sought to identify possible explanations for why these patients developed NEC, by comparing them with 5847 others that did not develop NEC, from the same hospitals and of the same gestational ages, cared for during the same 5½-year period.Study design: Data were collected from neonates admitted to any of the Intermountain Healthcare NICUs with a birth date from 1 January 2001 to 30 June 2006, and a gestational age >36 weeks. A variety of patient features and feeding practices were compared between those that did vs did not develop NEC.Result: Forty-one neonates >36 weeks gestation were listed in the discharge records as having NEC of Bell's stage II or higher. However, on review of these 41 medical records, 11 were seen to have had NEC of Bell's stage I, whereas the remaining 30 had radiographs and clinical courses indicative of Bell's stage XII. Those 30 formed the basis of this study. Twenty-eight of the 30 developed NEC after having been admitted to an NICU for some other reason; the other two developed NEC at home, within 2 days of being discharged from an NICU. The 30 that developed NEC were more likely than the 5847 that did not develop NEC, to have congenital heart disease (P ¼ 0.000), polycythemia (P ¼ 0.002), earlyonset bacterial sepsis (P ¼ 0.004) or hypotension (P ¼ 0.017). All 30 received enteral feedings before NEC developed; 29 were fed either artificial formula or a mixture of formula and breast milk. The one that was exclusively fed human milk was fed human milk with added fortifier (24 cal/oz). The 30 that developed NEC were more likely to be fed formula exclusively (P ¼ 0.000). Seven of the 30 had a laparotomy for NEC; two of the seven had total bowel necrosis and support was withdrawn. The other five had perforations and bowel resections. The mortality rate was 13% (4/30). Conclusion:In our series, NEC among term or near-term neonates was exclusively a complication developing among patients already admitted to a NICU for some other reason. We speculate that the combination of reduced mesenteric perfusion and feeding with artificial formula were factors predisposing them to develop NEC.

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Heparin-binding epidermal growth factor–like growth factor decreases the incidence of necrotizing enterocolitis in neonatal rats

Cited by 101 publications

References 19 publications

Effect of pasteurization on selected immune components of donated human breast milk

Effect of pasteurization on selected immune components of donated human breast milk

New Therapies and Preventive Approaches for Necrotizing Enterocolitis: Report of a Research Planning Workshop

Necrotizing enterocolitis in term neonates: data from a multihospital health-care system

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