Heparin‐binding protein (<scp>HBP</scp>): an early marker of respiratory failure after trauma?

Johansson, Joakim; Brattström, Olof; Sjöberg, Folke; Lindbom, Lennart; Herwald, Heiko; Weitzberg, Eddie; Oldner, Anders

doi:10.1111/aas.12070

Cited by 17 publications

(16 citation statements)

References 24 publications

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“…Both HBP and MPO peaked during CPB but had a rapid decline. The levels were still high four hours after surgery, with levels comparable to those measured during septic conditions 124,151,152 .…”

Section: Heparin Reversal With Protaminesupporting

confidence: 58%

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Hemostatic function and inflammatory activation after weaning from cardio pulmonary bypass

Olsson¹

2018

Linköping University Medical Dissertations

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Section: Heparin Reversal With Protaminesupporting

confidence: 58%

“…High levels of HBP has been found in patients with septic shock 150,151 and respiratory failure 152 . HBP can also be released when bacterial proteins directly activate neutrophils 152,153 .…”

Section: Heparin Reversal With Protaminementioning

confidence: 99%

Hemostatic function and inflammatory activation after weaning from cardio pulmonary bypass

Olsson¹

2018

Linköping University Medical Dissertations

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“…In critically ill patients, HBP was found to be associated with respiratory and circulatory failure, infection-related organ dysfunction, and mortality [47,48]. However, to our best knowledge, there is no previous publication on the role of HBP in CHF.…”

Section: Discussionmentioning

confidence: 99%

Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure

Branković

Akkerhuis

Mouthaan

et al. 2019

International Journal of Cardiology

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“…HBP injected directly into mice induced similar signs of lung damage, which could be blocked by heparin . In clinical settings, HBP levels have also been shown to be significantly higher in plasma from critically ill patients with acute respiratory distress syndrome (ARDS) compared to those without ARDS . Lin et al .…”

Section: Hbp As a Marker Of Specific Organ Failurementioning

confidence: 99%

Heparin‐binding protein: a key player in the pathophysiology of organ dysfunction in sepsis

2017

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Abstract. Fisher J, Linder A (University of Lund, Lund, Sweden). Heparin-binding protein: a key player in the pathophysiology of organ dysfunction in sepsis. (Review). J Intern Med 2017; 281: 562-574.Infectious diseases remain a major health problem, and sepsis and other severe infectious diseases are common causes of morbidity and mortality. There is a need for clinical and laboratory tools to identify patients with severe infections early and to distinguish between bacterial and nonbacterial conditions. Heparin-binding protein (HBP), also known as azurocidin or cationic antimicrobial protein of 37 KDa, is a promising biomarker to distinguish between patients with these conditions. It is biologically plausible that HBP is an early and predictive biomarker because it is prefabricated and rapidly mobilized from migrating neutrophils in response to bacterial infections. HBP induces vascular leakage and oedema formation and has a pro-inflammatory effect on a variety of white blood cells and epithelial cells. The dysregulation of vascular barrier function and cellular inflammatory responses can then lead to organ dysfunction. Indeed, it has been shown that patients with sepsis express elevated levels of HBP in plasma several hours before they develop hypotension or organ dysfunction. HBP has a major role in the pathophysiology of severe bacterial infections and thus represents a potential diagnostic marker and a target for the treatment of sepsis.

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Heparin‐binding protein (HBP): an early marker of respiratory failure after trauma?

Abstract: HBP is a potential biomarker candidate for early detection of ARDS development after trauma. Further research is required to confirm a casual relationship between plasma HBP and the development of ARDS.

Cited by 17 publications

References 24 publications

Hemostatic function and inflammatory activation after weaning from cardio pulmonary bypass

Hemostatic function and inflammatory activation after weaning from cardio pulmonary bypass

Utility of temporal profiles of new cardio-renal and pulmonary candidate biomarkers in chronic heart failure

Heparin‐binding protein: a key player in the pathophysiology of organ dysfunction in sepsis

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