Heparin cofactor II is degraded by heparan sulfate and dextran sulfate

Saito, Akio

doi:10.1016/j.bbrc.2015.01.028

Cited by 5 publications

(2 citation statements)

References 23 publications

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“…DS is a biodegradable, biocompatible and semi-synthetic sulfated polysaccharide composed of major 1-6 linkages and a minor 1-3 linkage of sulfated glucose of a branched structure, and is used in the biomedical field among other applications. Both DS and ChS have anticoagulant properties and furthermore, ChS may prevent vein hardening and DS reduce triacylglycerol in plasma [52]. In fact, these polymers have been considered to be very useful in the design of drug delivery systems and also as candidates for hybrid systems [50].…”

Section: Chondroitin Sulfate Dextran Sulfate and Heparan Sulfatementioning

confidence: 99%

Polysaccharide-Based Nanocarriers for Ocular Drug Delivery

Formica¹,

Calles²,

Palma

2015

CPD

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Obtaining successful ocular formulations able to support an efficient drug concentration at the target tissue for an appropriate period of time is an interesting challenge for modern pharmaceutical technology. In this sense, nanotechnology is one of the available strategies to obtain a drug carrier system that allows access to different compartments of the eye in order to deliver drugs to the desired site. Biodegradable polymers such as polysaccharides are promising biomaterials for the production of biocompatible and biodegradable nanocarriers (NCs). Different types of polysaccharide NCs are capable of improving the transport of drugs after ocular application and they can be either polysaccharide-matrix carriers or polysaccharide-coated carriers, depending on whether polysaccharide is used as a matrix or as a coating, respectively. This review focuses on recent advances achieved by polysaccharide-based NCs for the treatment of ocular disorders.

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Section: Chondroitin Sulfate Dextran Sulfate and Heparan Sulfatementioning

confidence: 99%

Polysaccharide-Based Nanocarriers for Ocular Drug Delivery

Formica¹,

Calles²,

Palma

2015

CPD

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“…Взаємодія між гепарином і АТ-III опосередковує більшість антикоаґуляційних ефектів. Їх зв'язування викликає конформаційні зміни в АТ-III, що прискорює в 1000 разів [3] його здатність інактивувати основні фактори згортання, включаючи тромбін (або фактор IIa) [61], фактори Xa (ФXa), IXa, XI і XII [5,6]. Він побічно впливає також на фактори V і VIII [9].…”

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Heparins: Mechanism of Action and Application in Acute Pancreatitis

Chooklin¹,

Pidhirnyy²,

Chuklin³

2015

Lʹviv. klin. visn.

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Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran

et al. 2017

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Sulfation (to 2.8) of dextrans with molecular weight of 150 and 20 kDa was followed by the appearance of anticoagulant activity that increased with decreasing their molecular weight and did not depend on antithrombin, plasma inhibitor of serine proteases of the blood coagulation system. Antithrombin activity of dextran sulfate with a molecular weight of 20 kDa reached 12.6-15.3 U/mg. Dextran sulfates with molecular weights of 20 and 150 kDa did not potentiate ADP-induced human platelet aggregation.

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Heparin cofactor II is degraded by heparan sulfate and dextran sulfate

Cited by 5 publications

References 23 publications

Polysaccharide-Based Nanocarriers for Ocular Drug Delivery

Polysaccharide-Based Nanocarriers for Ocular Drug Delivery

Heparins: Mechanism of Action and Application in Acute Pancreatitis

Effect of Sulfation and Molecular Weight on Anticoagulant Activity of Dextran

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