Heparin‐induced lipoprotein precipitation apheresis in dyslipidemic patients: A multiparametric assessment

Abstract

Low-density lipoprotein (LDL) apheresis (LA) selectively eliminates lipoproteins containing apolipoprotein B 100 (ApoB100) on patients affected by severe dyslipidemia. In addition to lowering lipids, LA is thought to exert pleiotropic effects altering a number of other compounds associated with atherosclerosis, such as pro-and anti-inflammatory cytokines or pro-thrombotic factors. More knowledge needs to be gathered on the effects of LA, and particularly on its ability to modify blood components other than lipids. We performed a multiparametric assessment of the inflammatory, metabolic and proteomic profile changes after Heparininduced lipoprotein precipitation (H.E.L.P.) apheresis on serum samples from nine dyslipidemic patients evaluating cholesterol and lipoproteins, plasma viscosity and density, metabolites, cytokines, PCSK9 levels and other proteins selectively removed after the treatment. Our results show that H.E.L.P. apheresis is effective in lowering lipoprotein and PCSK9 levels. Although not significantly, complement and inflammation-related proteins are also affected, indicating a possible transient epiphenomenon induced by the extracorporeal procedure.

Functionalized Periodic Mesoporous Silica Nanoparticles for Inhibiting the Progression of Atherosclerosis by Targeting Low-Density Lipoprotein Cholesterol

“…LDL-C is composed of TG, cholesterol esters (CE), and unesterified cholesterol (UC). Its surface is primarily composed of ApoB-100, which has the ability to bind to heparin, resulting in the precipitation of LDL-C [ 41 ]. Building upon the foundation of heparin, Li et al developed a magnetic nanocomposite material by conjugating heparin with chitosan.…”

Nomenclature of Extracorporeal Blood Purification Therapies for Acute Indications: The Nomenclature Standardization Conference

“…Heparin-Induced Extracorporeal LDL Precipitation Apheresis Heparin-induced extracorporeal LDL precipitation apheresis selectively removes lipoproteins containing apolipoprotein B100 in patients with severe dyslipidemia who show progressive atherosclerotic cardiovascular disease despite optimal treatment [28]. In addition to lowering lipids, heparin-induced extracorporeal LDL precipitation apheresis is thought to exert pleiotropic effects by modifying blood components other than lipids (cytokines, pro-thrombotic factors).…”