Heparin-Induced Thrombocytopenia

Nicolaides, Andrew; Fareed, Jawed; Kakkar, AK; Comerota, A. J.; Goldhaber, Samuel Z.; Hull, R. D.; Myers, K.; Samama, M; Fletcher, Jane; Kalodiki, Evi; Bergqvist, David; Bonnar, J.; Caprini, Joseph A.; Carter, C.; Conard, J; Eklöf, B; Elalamy, Ismaı̈l; Gerotziafas, Grigoris T.; Geroulakos, George; Giannoukas, A.; Greer, Ian A.; Griffin, Michael T.; Kakkos, S.; Lassen, Michael R.; Lowe, G. D. O.; Markel, A. L.; Prandoni, Paolo; Raskob, Gary E.; Spyropoulos, Alex C.; Turpie, Alexander G.G.; Walenga, Jeanine M.; Warwick, David

doi:10.1177/1076029612474840s

Cited by 3 publications

(1 citation statement)

References 118 publications

(197 reference statements)

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“…A good understanding and the appropriate application of other available laboratory tests for heparin-induced thrombocytopenic thrombosis is necessary, as the acute-onset devastating phlegmasia in our patient could also be explained by sepsis-induced disseminated intravascular coagulation and/or central venous catheter-triggered deep venous thrombosis [ 9 ]. The most accurate test for identifying heparin-induced thrombocytopenia antibodies is the 14C (radiolabeled) serotonin-release assay (SRA); however, it is time-consuming and highly dependent on the reactivity of the donor’s platelets.…”

Section: Discussionmentioning

confidence: 99%

Upper Limb Phlegmasia Cerulea Dolens Secondary to Heparin-induced Thrombocytopenia Leading to Gangrene

Kommalapati

Kallam²,

Krishnamurthy

et al. 2018

Cureus

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We present a case of a dialysis-dependent end-stage renal disease patient who originally presented with sepsis and later developed heparin-induced thrombocytopenia-related upper extremity deep venous thrombosis that rapidly progressed to phlegmasia. Argatroban, a direct thrombin inhibitor, was initiated without delay. Argatroban restored the venous patency completely but did not reverse his two gangrenous fingers. The patient finally underwent digital amputation. The management of this uncommon, but life-threatening, situation of upper limb phlegmasia cerulea dolens secondary to heparin-induced thrombocytopenia leading to gangrene is discussed in this case report.

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Section: Discussionmentioning

confidence: 99%

Upper Limb Phlegmasia Cerulea Dolens Secondary to Heparin-induced Thrombocytopenia Leading to Gangrene

Kommalapati

Kallam²,

Krishnamurthy

et al. 2018

Cureus

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Temporal and anatomic relationship between superficial and deep vein thromboses in hospitalized children

Doan

Cox

Rao

et al. 2021

Thrombosis Research

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Spontaneous acute superficial vein thrombosis of the legs: do we really need to treat?

Décousus

Bertoletti

Frappé

2015

Journal of Thrombosis and Haemostasis

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Summary Spontaneous acute superficial vein thrombosis (SVT) of the leg is now generally recognized as an integral component of venous thromboembolic disease with potentially severe consequences. However, the relatively low grades of some current international recommendations and uncertainty regarding the cost‐effectiveness of available therapies may prompt questioning of the real need to treat patients with SVT and explain the persisting heterogeneity of their management in practise. Yet several studies have consistently shown high rates of thromboembolic complications associated with SVT, whether at first presentation or during follow‐up. The CALISTO trial established for the first time the clinical benefit of a well‐defined anticoagulant regimen for the prevention of serious thromboembolic complications in SVT patients, and we believe that patients such as those included in this trial should receive this regimen as tested. However, several areas of uncertainty remain for categories of SVT patients not evaluated in CALISTO.

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Heparin-Induced Thrombocytopenia

Cited by 3 publications

References 118 publications

Upper Limb Phlegmasia Cerulea Dolens Secondary to Heparin-induced Thrombocytopenia Leading to Gangrene

Upper Limb Phlegmasia Cerulea Dolens Secondary to Heparin-induced Thrombocytopenia Leading to Gangrene

Temporal and anatomic relationship between superficial and deep vein thromboses in hospitalized children

Spontaneous acute superficial vein thrombosis of the legs: do we really need to treat?

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