Heparin‐like anticoagulant associated with systemic candidiasis

Abstract

A 15 year old girl with aplastic anemia developed a heparin-like anticoagulant during the course of systemic candidiasis. This was initially detected in the laboratory by an elevation of the thrombin clotting time which corrected with toluidine blue but not by mixing with normal plasma. In vivo and in vitro the anticoagulant was remarkably resistant to neutralization by protamine sulfate. Nevertheless, its heparin-like nature was confirmed by its sensitivity to heparinase and its dependence on antithrombin III.

Structural characterization and functional effects of a circulating heparan sulfate in a patient with hepatocellular carcinoma

“…In the few cases where the circulating heparinoid was indirectly and incompletely characterized, the majority have displayed characteristics consistent with heparan sulfate although dermatan sulfate has also been described [20]. There is also one reported case of heparinoid syndrome in a patient with systemic candidiasis and it has been reported in cancer patients who have received suramin [21,22]. Our patient represents the first case of heparinoid syndrome described in association with hepatocellular carcinoma.…”

Circulating heparin‐like anticoagulants: Case report and review of literature

“…The spectrum of associated conditions includes hematologic malignancies, most commonly plasma cell dyscrasias and systemic mastocytosis, [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] and solid tumors, often with metastases. [18][19][20][21][22][23][24] There have also been reported cases of infection, 25,26 allergy, 27 pregnancy, 28 and renal disease 29 associated with circulating heparin-like anticoagulants.…”