Heparin prevents the cytotoxic activity of Bothrops jararacussu and Apis mellifera venoms in renal cells

Teixeira-Cruz, Jhonatha M.; Martins-Ferreira, Jainne; Monteiro-Machado, Marcos; Strauch, Marcelo A.; Moraes, João Alfredo; Amaral, Luciana S; Valente, Raphael C; Melo, Paulo A.; Quintas, Luis Eduardo M.

doi:10.1016/j.toxicon.2022.107011

Cited by 1 publication

(1 citation statement)

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“…Bee venom contains allergens and toxins that can cause allergic or toxic reactions in the body [ 7 , 8 ]. Allergic reactions are relatively easy to treat, but toxicity can lead to severe acute renal failure, liver failure, multiple organ failure, and even death [ 9 , 10 ]. The analysis of serum metabolomics in patients stung by bees may provide new insights into the pathogenic mechanism of bee stings and provide a theoretical basis for reducing multiple organ failure and death in clinical practice.…”

Section: Introductionmentioning

confidence: 99%

Being Stung Once or Twice by Bees (Apis mellifera L.) Slightly Disturbed the Serum Metabolome of SD Rats to a Similar Extent

Wang,

Zheng,

Wang

et al. 2024

IJMS

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In most cases, the number of honeybee stings received by the body is generally small, but honeybee stings can still cause serious allergic reactions. This study fully simulated bee stings under natural conditions and used 1H Nuclear Magnetic Resonance (1H NMR) to analyze the changes in the serum metabolome of Sprague–Dawley (SD) rats stung once or twice by honeybees to verify the impact of this mild sting on the body and its underlying mechanism. The differentially abundant metabolites between the blank control rats and the rats stung by honeybees included four amino acids (aspartate, glutamate, glutamine, and valine) and four organic acids (ascorbic acid, lactate, malate, and pyruvate). There was no separation between the sting groups, indicating that the impact of stinging once or twice on the serum metabolome was similar. Using the Principal Component Discriminant Analysis ( PCA-DA) and Variable Importance in Projection (VIP) methods, glucose, lactate, and pyruvate were identified to help distinguish between sting groups and non-sting groups. Metabolic pathway analysis revealed that four metabolic pathways, namely, the tricarboxylic acid cycle, pyruvate metabolism, glutamate metabolism, and alanine, aspartate, and glutamate metabolism, were significantly affected by bee stings. The above results can provide a theoretical basis for future epidemiological studies of bee stings and medical treatment of patients stung by honeybees.

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