Heparin promotes fibrillation of most phenol-soluble modulin virulence peptides from Staphylococcus aureus

Abstract

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Crosslinking of dialdehyde heparin: a new strategy for improving the anticoagulant properties of porcine acellular dermal matrix

“…2b shows the FTIR spectrum of LMWH and OL, it was found that both of them had characteristic absorption peaks at 892 cm −1 and 936 cm −1 . 23,24 The C–O–S stretching vibration absorption peak of the sulfuric acid group on amino hexose appeared around 830 cm −1 , the strong absorption peak of O–S stretching vibration appeared around 1240 cm −1 , and the CO stretching vibration peak of the sulfuric acid group in the carboxyl group appeared around 1621 cm −1 was also found in both, all of these indicated that the main structure of the OL obtained after oxidation did not change significantly. It has been known that the reason for the conspicuous anticoagulant activity and cytocompatibility of LMWH is the presence of a reactive pentose structure in its molecular chain, 25 they can bind to antithrombin III (AT III), change the conformation of the antithrombin molecules, and inhibit the activity of coagulation factors IIa, Xa and IXa, exhibiting strong anticoagulant properties.…”

Functional amyloids from bacterial biofilms – structural properties and interaction partners

“…In the case of PSMβ2 heparin is even capable of altering the dominating molecular mechanism of aggregation from primary nucleation and elongation dominated to being dominated by secondary nucleation. 183 …”

“…In the case of PSMb2 heparin is even capable of altering the dominating molecular mechanism of aggregation from primary nucleation and elongation dominated to being dominated by secondary nucleation. 183 In summary, the formation of functional amyloids in the extracellular environment of the biolm appears to be optimized ensuring that the biomolecules in the biolm are generally benecial for the aggregation process.…”

The Bacterial Amyloids Phenol Soluble Modulins from Staphylococcus aureus Catalyze Alpha-Synuclein Aggregation

“…The pH modulation of their aggregation mechanisms was recently reported (41) with PSMα1 found to aggregate through a mechanism dominated by secondary nucleation at neutral pH. Other factors also modulate PSM fibrillation, such as the sulfated polysaccharide heparin [ 22 ]. The production of PSMα peptides by S. aureus is stringently regulated and is associated with virulence.…”