Heparin therapy for deep venous thrombosis

Weight-Based Argatroban Dosing Nomogram for Treatment of Heparin-Induced Thrombocytopenia

“…Multiple studies with heparin and argatroban have confirmed that this therapeutic threshold significantly reduces the rate of thrombotic events or death from thrombosis. [33][34][35][36][37][38] An aPTT of 1.5 times the control level is accepted as the minimum level of anticoagulation needed for therapeutic efficacy with argatroban. In our study, 88.3% of patients whose dosing was determined with the standard nomogram and 76.5% of those treated in accordance with the hepatic/critically ill nomogram achieved aPTT values above the therapeutic threshold of 45 seconds or more within 6 hours after argatroban was initi- 18,19 None of the patients in our study experienced a VTE event after treatment with argatroban.…”

Propagation of deep venous thrombosis identified by duplex ultrasonography

“…However, despite widespread acceptance of anticoagulation for therapy of DVT, there remains controversy over its efficacy. Several investigations 26' 28 have shown an increased incidence of thromboembolic complications when anticoagulation was inadequate, leading Kashtan et al 29 to recommend large doses of heparin to treat DVT. Nevertheless, the frequency of death, recurrent embolism, bleeding during treatment, and occurrence of late deep venous insufficiency has varied widely in separate reports.…”

Non-traumatic thoracic emergencies: CT diagnosis of acute pulmonary embolism: the first 10 years

“…When untreated, PE is fatal in up to 30% of patients, which can be reduced to 2-10% if diagnosed and treated promptly with anticoagulation [1,5,6,7]. Such therapy, however, is not without risk with an estimated 10-30% complication rate [8,9,10,11,12,13]. Pulmonary embolism therefore requires sensitive and specific diagnostic examinations.…”