Skin discoloration, also known as skin decolorization, is an uncommon side effect that can occur after low molecular weight heparin (LMWH) is administered. We describe the case of a 33-year-old woman who complained of searing pains in both feet, feverish spells, and other symptoms when she visited the emergency room. She did, however, experience increased symptoms after receiving LMWH, such as abrasions and skin discolouration on her upper and lower limbs. This case emphasizes how crucial it is to take unusual drug reactions into account when treating patients who exhibit dermatological symptoms.