Heparinized bottles for the collection of body cavity fluids in cytopathology

Roffe, Bruce D.; Wagner, Frederick (sic) H.; Derewicz, Henry J.; Gill, Gary W.

doi:10.1093/ajhp/36.2.211

Cited by 5 publications

(3 citation statements)

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“…The addition of heparin (3 units/mL of fluid) as an anticoagulant does not interfere with cytologic details, [1,16,17] but it may interfere with the quality of Romanowsky stains due to background staining. Anticoagulants such as acid citrate dextrose [16] and disodium EDTA [18,22,23] do not interfere with the cellular morphology.…”

Section: Anticoagulantsmentioning

confidence: 99%

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Collection and processing of effusion fluids for cytopathologic evaluation

Shidham¹

2022

Cytojournal

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Accumulation of fluid in serous cavities as effusions may have to be drained for therapeutic and diagnostic indications. As compared to many other procedures, the technicality of paracentesis procedures is relatively easy. As a result, effusion fluids comprise a significant proportion of specimens in most of the laboratories, including those in community settings. Because of relative complexities in the cytopathologic evaluation of effusion fluids, application of appropriately standardized protocol is critical for achieving optimum results by applying standardized steps from handling of specimens during the initial stages of collection to the final interpretation phase. Understanding various limitations and challenges during collection and processing phases by all the personnel involved, including clinicians, pathologists, and technologists is critical for optimum diagnostic yield. This review highlights various cytopreparatory techniques applicable to effusion cytology in one place. It is organized by projecting the details predominantly in the form of different tables and figures including summary of the recommended protocols with reagents and stains used. Also included is a sample of cytopathology report based on the approach discussed in this series.

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Section: Anticoagulantsmentioning

confidence: 99%

“…Fresh without anticoagulant OR Fresh with anticoagulant-Heparin ¶ [1,16,17] Acid citrate dextrose [16] Di-sodium EDTA [18] *OR (rarely if delayed transport or storage at higher room temperature cannot be avoided) e specimen may be collected in:…”

Section: Collectionmentioning

confidence: 99%

Collection and processing of effusion fluids for cytopathologic evaluation

Shidham¹

2022

Cytojournal

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show abstract

“…3 If heparinized bottles are not available, the heparin can be poured into the bottle before the fluid is collected; contact with glass results in rapid clotting. To prevent clotting, which widely disperses cells, thus hindering their evaluation, fluid can be collected in heparinized bottles containing 3 units of heparin per milliliter of capacity.…”

mentioning

confidence: 99%