2015
DOI: 10.1186/s40635-015-0072-z
|View full text |Cite
|
Sign up to set email alerts
|

Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction

Abstract: BackgroundThe beneficial effects of heparin in the treatment of severe sepsis, septic shock, and sepsis-associated disseminated intravascular coagulation (DIC) have recently been reported. However, the mechanisms underlying the therapeutic benefits of heparin in these conditions have not yet been clearly elucidated. The purpose of this study was to confirm the effect of heparin of neutralizing histone toxicity.MethodsRat models of histone H3-induced organ dysfunction were administered in a low or high dose of … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

2
69
0
2

Year Published

2016
2016
2023
2023

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 83 publications
(73 citation statements)
references
References 31 publications
2
69
0
2
Order By: Relevance
“…Caecal ligation and puncture (CLP) surgery was performed as previously described 51 . Briefly, 7 mm of the tip of the caecum was ligated using 4.0 silk sutures and the tip pierced twice with a 21G needle to produce two punctures.…”
Section: Methodsmentioning
confidence: 99%
“…Caecal ligation and puncture (CLP) surgery was performed as previously described 51 . Briefly, 7 mm of the tip of the caecum was ligated using 4.0 silk sutures and the tip pierced twice with a 21G needle to produce two punctures.…”
Section: Methodsmentioning
confidence: 99%
“…In addition to the pathogen, histones released from damaged cells can also cause endothelial injury 17 . Heparin can antagonize histones and thus “protect” the endothelium 18,19 . This protective function can be extended to the endothelial tight junctions as demonstrated in a sepsis model, in which unfractionated heparin could decrease lung edema and vascular leakage following lipopolysaccharide‐induced injury 20 .…”
Section: Figurementioning
confidence: 99%
“…Histones and histone fragments are parts of an ancient antimicrobial mechanism conserved throughout eukaryotic species. In mammals, packaging of histones into NETs and interaction with the coagulation cascade presents an effective mechanism of limiting the spread of Heparin (unfractionated and/or low molecular weight) [166] thrombosis, worsens tissue perfusion and contributes significantly to organ injury. Recognition of this phenomenon may allow targeted therapy, limiting systemic injury and improving survival.…”
Section: Conclusion Smentioning
confidence: 99%