Hepatic abscess due to Dialister pneumosintes - A case report

Soeiro, Cristina; Quilici, Isabela Rosado; Lefèvre, Brigitte; Oussalah, Mouni Bensenane; Morin, Mathilde; Alauzet, Corentine; Charmillon, Alexandre

doi:10.1016/j.anaerobe.2019.05.006

Cited by 13 publications

(8 citation statements)

References 12 publications

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“… 22 The present case also highlights the efficacy of genetic testing in identifying microorganisms that are difficult to culture, such as D. pneumosintes , as is also described in a previous study. 17 Although the most common pathogen of LS is an anaerobe, 13 at times it is difficult to identify it by conventional methods even in a culture-positive situation as described in the present case report. In this situation, the use of 16S rRNA sequencing is helpful to identify the causative organism, thereby providing specific clues for the infected organ and correct selection of antibacterial agents, along with the determination of the treatment period.…”

Section: Discussionmentioning

confidence: 69%

Lemierre Syndrome Due to Dialister pneumosintes: A Case Report

Hirai¹,

Kuruma²,

Sakanashi³

et al. 2022

IDR

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Although Dialister pneumosintes is a commensal microorganism of the oral cavity, it may sometimes cause severe systemic infections. We report a case of Lemierre syndrome (LS), which developed after D. pneumosintes infection, in a 73-year-old Japanese woman who was admitted to the hospital for throat pain, neck swelling, and fever for 3 days. She had a 3-month history of neglected dental caries, gingivitis, and periodontitis. Physical examination revealed right tonsillar erythema and swelling, and computed tomography (CT) showed peritonsillar and retropharyngeal abscesses. Ampicillin/sulbactam was promptly administered after collecting two sets of blood cultures. Surgical drainage for peritonsillar and retropharyngeal abscesses was also conducted on the second hospital day. Although only commensal oral microflora grew in the culture from the drained pus, Gram-negative bacilli were confirmed in the anaerobic blood cultures. Metronidazole was administered intravenously; however, the fever and neck swelling persisted. Repeat CT performed on the fifth hospital day revealed right internal jugular vein thrombosis, a known complication of tonsillitis and pharyngitis once the infection extends beyond the oropharynx. We diagnosed she had coexisting LS, and anticoagulant therapy was added to her treatment regimen. Her condition improved, and she was discharged after completing 3 weeks of antibiotics. Conventional methods failed to identify the isolated bacterium, and 16S rRNA sequencing ultimately identified it as D. pneumosintes . In a literature review of bacteremia due to D. pneumosintes , poor oral hygiene was considered a probable risk factor for invasive D. pneumosintes infection. We consider this to be the case in our patient who presented with dental caries, gingivitis, and periodontitis. In addition, all cases revealed that the 16S rRNA gene sequencing is useful for identifying this species. Although the diagnosis of LS by physical examination is difficult, physicians should always consider it as a potential complication of infections in the pharyngeal area.

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Section: Discussionmentioning

confidence: 69%

Lemierre Syndrome Due to Dialister pneumosintes: A Case Report

Hirai¹,

Kuruma²,

Sakanashi³

et al. 2022

IDR

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“…Six of the reviewed cases show either a sinusal or dental focus as cause for the infection with D. pneumosintes [6,[13][14][15][16], the other reports don't further specify the supposed origin of D. pneumosintes even though all cases refer to D. pneumosintes as a known pathogen of the oropharyngeal cavity causing periodontitis and sinusitis as outlined before.…”

Section: Discussionmentioning

confidence: 99%

“…In 4 out of 10 cases, D. pneumosintes could be identified through cultivation of material obtained via intervention. Out of these four, D. pneumosintes was cultivated in two cases with pneumonia from a bronchoalveolar lavage [10,11] and in the other two cases from pus of a drained brain abscess and liver [14,16]. In total 6 of the 10 reviewed cases needed surgical treatment [6,[13][14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Severe Pneumonia and Sepsis Caused by Dialister pneumosintes in an Adolescent

et al. 2021

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Background: Dialister pneumosintes (D. pneumosintes) is known to cause dental, periodontal or sinus infections. To date, the pathogen has only been described in a small number of cases with a severe infection. Case report: We describe the clinical case of a 13-year-old, obese female patient that presented with acute respiratory failure and sepsis. A CT-scan showed extensive bilateral patchy areas, subpleural and peribronchovascular consolidations with surrounding ground-glass opacity, extensive consolidations in the lower lobes of both lungs matching to a severe pneumonia and clinically emerging acute respiratory distress syndrome. Moreover, it showed extensive sinusitis of the right sinus frontalis, maxillaris and right cellulae ethmoidales. D. pneumosintes was isolated from an anaerobic blood culture obtained at admission. The antibiotic treatment included piperacillin/tazobactam and oral switch to ampicillin/sulbactam plus ciprofloxacin. Conclusions: We describe the first adolescent with severe systemic D. pneumosintes infection. Since the pathogen is difficult to culture the systemic virulence remains unclear. This work aims to sensitize health care specialists to consider D. pneumosintes infection in patients with periodontal or sinusal infection.

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“…Thetaiotaomicron, Difficile, Oscillibacter, Ovatus, Methanobrevibacter, and Porphyromonas have been reported as opportunistic pathogens, and are implicated in IBD, IBS, ulcerative colitis, and CRC (Saitoh et al, 2002;Kim et al, 2012;Dai et al, 2018;Porter et al, 2018;Sandhu and McBride, 2018;Wu et al, 2019). Some other opportunistic pathogens, such as Parvimonas and Dialister are implicated with oral infections and liver abscesses (Chaucer et al, 2018;Soeiro et al, 2019). Coprococcus, Holdemania, Xylanisolvens, and Acidominococcus have been associated with increased consumption of dietary fiber and are considered as commensal bacteria (Voreades et al, 2014;Despres et al, 2016;Barrett et al, 2018).…”

Section: Cellmentioning

confidence: 99%

Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma

et al. 2020

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Colorectal cancer (CRC) and hepatocellular carcinoma (HCC) are the second and third most common causes of death by cancer, respectively. The etiologies of the two cancers are either infectious insult or due to chronic use of alcohol, smoking, diet, obesity and diabetes. Pathological changes in the composition of the gut microbiota that lead to intestinal inflammation are a common factor for both HCC and CRC. However, the gut microbiota of the cancer patient evolves with disease pathogenesis in unique ways that are affected by etiologies and environmental factors. In this review, we examine the changes that occur in the composition of the gut microbiota across the stages of the HCC and CRC. Based on the idea that the gut microbiota are an additional "lifeline" and contribute to the tumor microenvironment, we can observe from previously published literature how the microbiota can cause a shift in the balance from normal → inflammation → diminished inflammation from early to later disease stages. This pattern leads to the hypothesis that tumor survival depends on a less proinflammatory tumor microenvironment. The differences observed in the gut microbiota composition between different disease etiologies as well as between HCC and CRC suggest that the tumor microenvironment is unique for each case.

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Hepatic abscess due to Dialister pneumosintes - A case report

Cited by 13 publications

References 12 publications

Lemierre Syndrome Due to Dialister pneumosintes: A Case Report

Lemierre Syndrome Due to Dialister pneumosintes: A Case Report

Severe Pneumonia and Sepsis Caused by Dialister pneumosintes in an Adolescent

Gut microbiota alterations are distinct for primary colorectal cancer and hepatocellular carcinoma

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