Hepatic acute phase proteins – Regulation by IL-6- and IL-1-type cytokines involving STAT3 and its crosstalk with NF-κB-dependent signaling

Bode, Johannes G.; Albrecht, Ute; Häussinger, Dieter; Heinrich, Peter C.; Schaper, Fred

doi:10.1016/j.ejcb.2011.09.008

Cited by 328 publications

(264 citation statements)

References 82 publications

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“…Indeed, turpentine induced significant increases in transcription within 8 h of the classical markers of liver inflammation, SAA1, serum amyloid protein, and -1-acid glycoprotein (Fig. 6A), all proteins secreted by the liver into the serum in response to inflammatory signals, such as IL-1 and OSM (31). Although no changes were observed in mRNA levels of any of the ORMDLs, as measured by quantitative (Q)PCR (Fig.…”

Section: Irritant-induced Inflammation Decreased Ormdl Protein Expresmentioning

confidence: 94%

ORMDL proteins regulate ceramide levels during sterile inflammation

Cai

Oyeniran

Biswas

et al. 2016

Journal of Lipid Research

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Section: Irritant-induced Inflammation Decreased Ormdl Protein Expresmentioning

confidence: 94%

ORMDL proteins regulate ceramide levels during sterile inflammation

Cai

Oyeniran

Biswas

et al. 2016

Journal of Lipid Research

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“…The acute phase response is the answer of the organism to disturbances of homeostasis due to inflammation, tissue injuries or other disorders, and is helpful to restore the disturbed physiological homeostasis (Bode et al, 2012). Liver is the major site for the synthesis of acute phase proteins (APPs), including LPS-binding protein (LBP), C-reactive protein (CRP), serum amyloid A (SAA) and haptoglobin (HP) (Murata et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

High concentrate-induced subacute ruminal acidosis (SARA) increases plasma acute phase proteins (APPs) and cortisol in goats

Jia

Wang

et al. 2014

Animal

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The aim of this study was to investigate changes of stress status in dairy goats induced to subacute ruminal acidosis (SARA). The level of acute phase proteins (APPs) including haptoglobin (HP) and serum amyloid A (SAA) in plasma and their mRNA expression in liver, as well as plasma cortisol and genes expression of key factors controlling cortisol synthesis in adrenal cortex were compared between SARA and control goats. SARA was induced by feeding high concentrate diet (60% concentrate of dry matter) for 3 weeks (SARA, n = 6), while control goats (Con, n = 6) received a low concentrate diet (40% concentrate of dry matter) during the experimental time. SARA goats showed ruminal pH below 5.8 for more than 3 h per day, which was significantly lower than control goats (pH > 6.0). SARA goats demonstrated a significant increase of hepatic HP and SAA mRNA expression ( P < 0.05), and the level of HP but not SAA in plasma was markedly increased compared with control ( P < 0.05). The level of cortisol in plasma showed a trend to increase in SARA goats (0.05 < P < 0.1). In adrenal cortex, mRNA expression of 17α-hydroxylase cytochrome (P450 17α ) ( P < 0.01) and 3β-hydroxysteroid dehydrogenase (3β-HSD) ( P < 0.05) was significantly increased in SARA goats. The contents of 3β-HSD and P450 side-chain cleavage protein were increased by 58.6% and 39.4%, respectively, but did not reach the statistical significance ( P > 0.05). These results suggested that SARA goats experienced a certain stress status, exhibiting an increase in HP production and cortisol secretion.

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“…IL-6 is also expressed in HepG2 cells (Deng et al 2014) and is important in promoting the acute phase response as well as liver regeneration and obesity and insulin resistance. IL-6 induces the expression of c-reactive protein, serum amyloid A, fibrinogen, and haptoglobin (Bode et al 2012), while IL-6 knockout mice have impaired liver regeneration (Cressman et al 1996). The effect of IL-6 on obesity and glucose metabolism is more complex.…”

Section: The Effect Of 2425-[oh] 2 D 3 On Proinflammatory Cytokine Ementioning

confidence: 99%