Hepatic and Cardiac Oxidative Stress and Other Metabolic Changes in Broilers with the Ascites Syndrome

Dı́az-Cruz, Antonio; Nava, Cuauhtémoc Domínguez; Villanueva, Ruben D; Serret, Maurilio; Guinzberg, Raquel; Piña, Enrique

doi:10.3382/ps.0750900

Cited by 26 publications

(20 citation statements)

References 17 publications

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“…Indeed, oxidative injury with increased blood MDA content (Ozkan et al, 2007) and decreased anti-oxidative enzyme activity (Aksit et al, 2008) were involved in ascites or PHS broilers. It was also documented that broilers at risk of developing ascites syndrome showed oxidative damage in the heart, liver and lung Diaz-Cruz et al, 1996). Supplementation of anti-oxidants such as vitamin E, vitamin C, thioctic acid and selenium can ameliorate oxidative stress and reduce ascites or PHS related mortality Diaz-Cruz et al, 2003;Pan et al, 2005;Aksit et al, 2008).…”

Section: Discussionmentioning

confidence: 92%

Changes of haematic parameters, redox status and mitochondrial complex activity in the heart and liver of broilers fed with different density diets under low ambient temperature

et al. 2013

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This experiment was conducted to investigate the influence of dietary nutrient density on haematic parameters, oxidative status and mitochondrial complex activity in the heart and liver of broilers under low ambient temperature. Eight-day-old male ROSS-308 chickens were randomly divided into two treatments fed with normal (control) and high metabolizable energy (ME) and crude protein density (H) diets. A high nutrient density diet increased body weight gain and reduced the feed conversation ratio during the first 3 weeks. Increased ascites-related mortality (weeks 4 to 6), right ventricle/total ventricle (week 6), blood haemoglobin (weeks 2 and 4) and mean corpuscular haemoglobin (week 2) were observed in treatment H. Levels of malonaldehyde and protein carbonylation were increased at week 4, and activities of glutathione peroxidase at week 4 and CuZn superoxide dismutase and catalase at week 6 were decreased in the heart; only malonaldehyde (week 6) was increased in the liver in treatment H. Relative mRNA expression of hypoxia inducible factor-1 (heart) was increased and heme oxygenase-1 (heart and liver) was decreased at week 4 in broilers fed with high ME and protein diet. Activities of mitochondrial complex III and IV (week 6) in the heart, and complex I (week 6) and complex III and IV (week 4) in the liver were decreased in treatment H. In conclusion, high levels of dietary ME and protein resulted in oxidative stress and high incidence of ascites in broilers under low ambient temperature. Heart dysfunction was primarily attributed to ascites development, in which oxidative injury and inhibition of mitochondrial complex activity were involved.

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Section: Discussionmentioning

confidence: 92%

Changes of haematic parameters, redox status and mitochondrial complex activity in the heart and liver of broilers fed with different density diets under low ambient temperature

et al. 2013

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“…Subsequent studies reported that vitamin E pellets implanted under the skin were effective in lowering ascites mortality in broilers, apparently by attenuating the processes leading to lipid peroxidation . Diaz-Cruz et al (1996) found that liver cells from broilers exhibiting ascites syndrome presented changes that were compatible with those observed in cases of oxidative stress. Bottje et al (1998) reported that the presence of oxidized glutathione in the lung lining¯uid of broilers was positively correlated with right ventricle:total ventricle weight ratios.…”

Section: Effect Of Cellular Damagementioning

confidence: 57%

Ascites Syndrome (Pulmonary Hypertension Syndrome) in Broiler Chickens: Are We Seeing the Light at the End of the Tunnel?

Balog¹

2003

Avian & Poul. Biolog. Rev.

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Ascites syndrome in broilers is a cascade of events that result in cardiac anomalies including an enlarged, flaccid heart, and right ventricular hypertrophy, as well as an accumulation of fluid in the abdominal cavity. Ascites was first noticed as a problem for commercial poultry producers, at farms that were located at high altitudes. Within the last 3 decades, however, ascites has become a significant problem for producers everywhere. Ascites fluid accumulation can be caused by many different factors. There are four general categories of dysfunctions that will result in ascites fluid build-up: (1) vascular damage that allows capillaries to leak; (2) blockage of the lymphatic system that prevents drainage; (3) decreased plasma oncotic pressure; and the most frequently seen dysfunction, (4) increased vascular hydraulic pressure. Increased vascular hydraulic pressure can be caused by several types of pathologies including hepatic, cardiac or right atrioventricular, and the most significant, pulmonary hypertension. Pulmonary hypertension accounts for most cases of ascites seen in commercial broilers, yet the hypertension can originate from many different causes. Environmental causes such as altitude, cold stress and incubator environment will affect the incidence of ascites. Management also plays a significant role in ascites development, for example; feed, lighting, air quality and ventilation have all been implicated in ascites development. Anatomy and physiology of the modern broiler also influences the incidence of ascites. Growth rate, oxygen requirements, organ size and capacity, hematological parameters and cellular responses can all determine how resistant or susceptible a broiler is to ascites. All of these factors cause ascites by inducing hypoxia in the bird (Julian, 1987(Julian, , 1988.The bird's demand for oxygen exceeds its cardiopulmonary capacity resulting in pulmonary hypertension. One final area that not only greatly influences, but also has potential to end ascites syndrome, is the area of genetic selection. In the past, a lot of the blame for our current ascites situation has been placed on poultry breeding and genetic selection for rapid growth, high meat yield and good feed conversion.While genetic selection may have exacerbated the ascites problem, it is also our best solution for eliminating this disorder in the near future.The selection of ascites resistant lines of broilers not only provides birds that can be raised at their maximal growth rate, it also provides a population in which to determine the exact molecular basis for ascites and pulmonary hypertension.

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“…The central etiology of AS is a hypoxemic condition (hypoxemia refers to blood in the systemic arteries that is under saturated with oxygen; Wideman et al, 2013) resulting from an imbalance between demand and supply of oxygen (Kalmar et al, 2013). Bakonyi & Radak (2004) reported that exposure to high altitude increases the formation of reactive oxygen species (ROS) and reactive nitrogen species, and ROS cause lipid peroxidation in heart and liver of broilers (Díaz-Cruz et al, 1996). Bottje et al (1995) reported that oxidative stress is associated with AS.…”

Section: Introductionmentioning

confidence: 99%

Lipid Peroxidation in the Plasma, Lungs, Heart and Liver of Broilers Fed a Grape Seed Extract and Raised at 2278 m of Altitude

Rodríguez-Ortega

Juárez-Juárez

Pró-Martínez

et al. 2017

Rev. Bras. Cienc. Avic.

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Grape seed extract, high altitude, lipid peroxidation, vitamin E. ABSTRACTThe aim of this research was to evaluate the effect of partial substitution of vitamin E (VE) by grape seed extract (GSE) on glutathione peroxidase activity (GPxA), nitric oxide (NO) concentration and lipid peroxidation [malondialdehyde (MDA) concentration] in the plasma, lungs, heart and liver, and live performance of broilers raised at 2278 m of altitude. One-d-old Ross 308 male chickens (n = 420) were randomly distributed into three treatments: Control-AL (basal diet containing 40 IU of VE and fed ad libitum; AL), Control-FR (basal diet and feed restriction; FR) and GSE-AL [basal diet containing 10 mg of GSE (equivalent to 30 IU VE) plus 10 IU of VE and fed AL]. The data were analyzed using one-way analysis of variance. Glutathione peroxidase activity, and NO and MDA concentrations in the plasma were evaluated on d 46. On d 47, MDA was evaluated in the lungs, heart and liver. Live performance parameters were recorded weekly. There were no significant differences (p>0.05) in live performance and NO concentration among treatments. Birds from the GSE-AL treatment presented the lowest (p<0.05) GPxA, the highest (p<0.05) MDA concentration in the plasma, heart and liver, and intermediate MDA concentration in the lungs. Our results suggest that GSE may partially replace VE in broiler diets without impairment of live performance. However, further research is required to determine the optimal level of dietary GSE inclusion to reduce lipid peroxidation in the plasma, lungs, heart, and liver of broilers raised at 2278 m of altitude.

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Hepatic and Cardiac Oxidative Stress and Other Metabolic Changes in Broilers with the Ascites Syndrome

Cited by 26 publications

References 17 publications

Changes of haematic parameters, redox status and mitochondrial complex activity in the heart and liver of broilers fed with different density diets under low ambient temperature

Changes of haematic parameters, redox status and mitochondrial complex activity in the heart and liver of broilers fed with different density diets under low ambient temperature

Ascites Syndrome (Pulmonary Hypertension Syndrome) in Broiler Chickens: Are We Seeing the Light at the End of the Tunnel?

Lipid Peroxidation in the Plasma, Lungs, Heart and Liver of Broilers Fed a Grape Seed Extract and Raised at 2278 m of Altitude

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