Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling

Koo, Hyun Jung; Lee, Sungryul; Chang, Kwang Jin; Sohn, Eunsoo; Sohn, Eun‐Hwa; Kang, Se Chan; Pyo, Suhkneung

doi:10.1016/j.biopha.2017.05.036

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…Among these hub genes, TLR4 represents the intersection of metabolism and immunity, thereby playing a vital role in HFD-induced inflammation. TLR4 also regulates the expression of the inflammatory cytokine TNFα through the classical pathway [ 11 , 32 , 33 ]. The PLCG2-IP3-Ca 2+ cascade activates TLR4 translocation, and TLR4 mediates the expression of IRF3 regulatory genes with SYK [ 34 – 36 ].…”

Section: Resultsmentioning

confidence: 99%

Rotundic acid improves nonalcoholic steatohepatitis in mice by regulating glycolysis and the TLR4/AP1 signaling pathway

Shi,

Zheng,

Liu

et al. 2023

Lipids Health Dis

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Background Steatosis and inflammation are the hallmarks of nonalcoholic steatohepatitis (NASH). Rotundic acid (RA) is among the key triterpenes of Ilicis Rotundae Cortex and has exhibited multipronged effects in terms of lowering the lipid content and alleviating inflammation. The study objective is to systematically evaluate the potential mechanisms through which RA affects the development and progression of NASH. Methods Transcriptomic and proteomic analyses of primary hepatocytes isolated from the control, high-fat diet-induced NASH, and RA treatment groups were performed through Gene Ontology analysis and pathway enrichment. Hub genes were identified through network analysis. Integrative analysis revealed key RA-regulated pathways, which were verified by gene and protein expression studies and cell assays. Results Hub genes were identified and enriched in the Toll-like receptor 4 (TLR4)/activator protein-1 (AP1) signaling pathway and glycolysis pathway. RA reversed glycolysis and attenuated the TLR4/AP1 pathway, thereby reducing lipid accumulation and inflammation. Additionally, lactate release in L-02 cells increased with NaAsO2-treated and significantly decreased with RA treatment, thus revealing that RA had a major impact on glycolysis. Conclusions RA is effective in lowering the lipid content and reducing inflammation in mice with NASH by ameliorating glycolysis and TLR4/AP1 pathways, which contributes to the existing knowledge and potentially sheds light on the development of therapeutic interventions for patients with NASH.

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Section: Resultsmentioning

confidence: 99%

Rotundic acid improves nonalcoholic steatohepatitis in mice by regulating glycolysis and the TLR4/AP1 signaling pathway

Shi,

Zheng,

Liu

et al. 2023

Lipids Health Dis

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“…As a receptor for LPS, the upregulation of TLR4 is responsible for the sustained activation of the cells involved in autoantibody production [47,48]. e extract of RD has the effect of downregulating the protein level of TLR4 and suppressing the increased levels of inflammatory cytokines [49]. Cytokines can be produced when the NF-κB signaling pathway is activated during the progression of a direct autoantibody-mediated tissue injury and the deposition of complement-fixing immune complexes, inducing chronic inflammatory response.…”

Section: Discussionmentioning

confidence: 99%

Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology

Yang

Xie

Zhong

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Systemic lupus erythematosus (SLE) is a refractory autoimmune disease. Zhibai Dihuang Wan (ZDW) has frequently been used for treating SLE in China and been proved to have a prominent role in decreasing SLE patients’ morality rate. However, the active substances in ZDW and the molecular mechanisms of ZDW in SLE remain unclear. This study identified the bioactive compounds and delineated the molecular targets and potential pathways of ZDW by using a network biology approach. First, we collected putative targets of ZDW based on TCMSP, GeneCards, and STITCH databases and built a network containing the interactions between the putative targets of ZDW and known therapeutic targets of SLE. Then, the key hubs were imported to DAVID Bioinformatics Resources 6.7 to perform gene ontology biological process (GOBP) and pathway enrichment analysis. A total of 95 nodes including 73 putative targets of ZDW were determined as major hubs in terms of their node degree. The results of GOBP and pathway enrichment analysis indicated that putative targets of ZDW mostly were involved in various pathways associated with inflammatory response and apoptosis. More importantly, eleven putative targets of ZDW (CASP3, BCL2, BAX, CYCS, NFKB1, NFKBIA, IL-6, IL-1β, PTGS2, CCL2, and TNF-α) were recognized as active factors involved in the main biological functions of treatment, implying the underlying mechanisms of ZDW acting on SLE. This study provides novel insights into the mechanisms of ZDW in SLE, from the molecular level to the pathway level.

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“… DioscoreapolystachyaTurcz. Liver disorders and Diabetes [ 31 ] 8. Salvia miltiorrhiza Bunge Inflammations Cardiovascular and circulatory disorders [ 32 ] 9.…”

Section: Antiviral Effectsmentioning

confidence: 99%

Role of natural products towards the SARS-CoV-2: A critical review

Raman

Rajagopal

Islam

et al. 2022

Annals of Medicine &Amp; Surgery

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Hepatic anti-inflammatory effect of hexane extracts of Dioscorea batatas Decne: Possible suppression of toll-like receptor 4-mediated signaling

Cited by 6 publications

References 40 publications

Rotundic acid improves nonalcoholic steatohepatitis in mice by regulating glycolysis and the TLR4/AP1 signaling pathway

Rotundic acid improves nonalcoholic steatohepatitis in mice by regulating glycolysis and the TLR4/AP1 signaling pathway

Potential Molecular Mechanisms of Zhibai Dihuang Wan in Systemic Lupus Erythematosus Based on Network Biology

Role of natural products towards the SARS-CoV-2: A critical review

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