Over the past decade, increasing use of chemo-embolization with chemotherapeutic agents emulsified in oil has been made in the treatment of both primary and metastatic liver tumours. These lesions are often not amenable to surgical resection and are not responsive to systemic chemotherapy. Chemo-embolization provides an additional therapeutic option which, in some instances, can provide significant benefit. This pictorial review discusses the technique of chemo-embolization, as well as aspects of patient selection, complications, and tumour response.