Hepatic Artery Stenosis After Liver Transplantation-Incidence, Presentation, Treatment, and Long Term Outcome1

Abstract

Little is known about hepatic artery (HA) patency and patient clinical course when the nonthrombosed HA has been revised. We undertook this study to evaluate the risk factors in the development of HA stenosis and to assess the impact of HA revision on the outcome. A total of 857 adult consecutive OLT in 780 patients performed over a 6-year period were studied. Patients who underwent revision of their nonthrombosed but stenotic HA were reviewed for patient/graft survival, method of HA revision, incidence of biliary strictures, and long-term HA patency. Overall 39 patients (5%) with 41 allografts underwent HA revision for stenosis. Median time to diagnosis was 100 days posttransplant (range 1-1220 days). HA flow at the time of OLT was found to be the only significant variable of an anastomotic stenosis. No risk factor could be identified for the graft HA stenosis. Treatment methods included resection of the stenotic segment with primary reanastomosis (n = 17), aortohepatic iliac artery graft (n = 11), interposition vein graft (n = 4), vein patch angioplasty (n = 2), interposition artery graft (n = 1), and percutaneous transluminal balloon angioplasty (n = 6). Postrevisional HA patency was demonstrated in 32 (78%) cases. At a median follow-up of 25 months, 26 patients (67%) were asymptomatic with good liver function. Nine patients had developed biliary strictures. Seven patients had undergone retransplantation and 8 patients had died. The actuarial patient and graft survivals at 4 years in the patients with revised HA were 65% and 56%, respectively. HA stenosis requiring revision is an infrequent occurrence after OLT. Long-term patency of the revised HA is good. Revision of the HA may help prevent biliary strictures and allow for good long-term graft function in the majority of patients.

Endovascular treatment of acute arterial complications after living-donor liver transplantation

“…Mean time to diagnosis of hepatic artery stenosis was reported to be as long as 100 days post-transplant. 17 The inclusion criterion of enrolling patients within 4 weeks of transplantation may be the reason that no cases of hepatic artery stenosis were found in the present study.…”

Twenty years of follow-up of aortohepatic conduits in liver transplantation

“…Thrombosis of the hepatic artery and the conduit remains the major problem. [9][10][11][12][13] We believe that meticulous surgical technique, aggressive surveillance, and early intervention are very important in preventing and treating this complication. We also by policy place such recipients on salicylic acid (80 mg once daily) as prophylaxis.…”

Metabolic changes in the liver graft monitored continuously with microdialysis during liver transplantation in a pig model

“…Hepatic artery thrombosis is one of the most devastating complications in orthotopic liver transplantation and occurs in 3% to 12% of all adult transplant recipients and up to 42% of pediatric patients. [3][4][5] Portal vein complications occur less commonly, with reported frequencies in 1% to 2% of cases. [4][5][6] New techniques are needed to monitor the transplanted liver and give information on early posttransplantation liver function before chemical events are reflected in peripheral-blood test results.…”