Hepatic Artery Thrombosis and Takotsubo Syndrome After Liver Transplantation – Which Came First?

Luu, Lydia A.; Rawashdeh, Badi; Goldaracena, Nicolás; Ágarwal, Avinash Kumar; McCracken, Emily; Sahli, Zeyad T.; Oberholzer, José; Pelletier, Shawn J.

doi:10.12659/ajcr.920263

Cited by 6 publications

(6 citation statements)

References 24 publications

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“…Although physicians describe a benign and transient clinical course in 90% of cases, this syndrome is often associated with electrical instability, cardiogenic shock, ventricular arrhythmias, heart failure, and pulmonary edema, characterized by high morbidity and mortality. Several etiological theories have been proposed to explain the pathogenesis of Takotsubo syndrome; the excess of circulating catecholamines, microvascular dysfunction, and intense coronary spasms have been taken into consideration, but the exact pathogenetic mechanism has not yet been understood [ 46 , 47 , 84 , 85 , 86 , 87 , 88 ]. Excess catecholamines directly affect cardiomyocytes with myocardial stunning (stunning), coronary vasospasm, myocardial ischemia, microcirculatory dysfunction, and left ventricular dysfunction [ 46 , 85 , 88 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several etiological theories have been proposed to explain the pathogenesis of Takotsubo syndrome; the excess of circulating catecholamines, microvascular dysfunction, and intense coronary spasms have been taken into consideration, but the exact pathogenetic mechanism has not yet been understood [ 46 , 47 , 84 , 85 , 86 , 87 , 88 ]. Excess catecholamines directly affect cardiomyocytes with myocardial stunning (stunning), coronary vasospasm, myocardial ischemia, microcirculatory dysfunction, and left ventricular dysfunction [ 46 , 85 , 88 ].…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, TC manifests itself early, simulating myocardial infarction with chest pain, dyspnea, and syncope. Still, the absence of coronary pathology on angiographic examination helps to differentiate the two pathological entities [ 46 , 84 , 86 , 88 , 89 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

Argo,

Pitingaro,

Puntarello

et al. 2024

Diagnostics

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Frequent and excessive consumption of alcohol, be it episodic or sustained misuse, ranks among the top causes of mortality globally. This comprehensive analysis seeks to elucidate how alcohol misuse precipitates death, with a particular focus on associated cardiac anomalies. Notably, the phenomenon of “Holiday Heart Syndrome”, linked to binge drinking, is recognized for inducing potentially fatal cardiac arrhythmias. Moreover, persistent alcohol consumption is implicated in the development of alcoholic cardiomyopathy, a condition that underlies heart failure and arrhythmic disturbances of the heart. Additionally, individuals undergoing withdrawal from alcohol frequently exhibit disruptions in normal heart rhythm, posing a risk of death. This review further delves into additional alcohol-related mortality factors, including the heightened likelihood of hypertension, cerebrovascular accidents (strokes), and the connection between excessive alcohol use and Takotsubo syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

Argo,

Pitingaro,

Puntarello

et al. 2024

Diagnostics

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“…Furthermore, TTS patients after OLT were found to have other complications post-incident, including cerebrovascular accidents, liver failure, gastrointestinal bleeding, and an increased requirement for invasive mechanical ventilation and renal replacement therapy 5 , 9 . Hepatic artery thrombosis as a potential consequence of TTS after OLT has also been reported 28 . After OLT, TTS patients required higher resource utilization in the form of mechanical ventilation, haemodialysis, vasopressors, and intra-aortic balloon pumps (IABP).…”

Section: Methodsmentioning

confidence: 99%

Cardiomyopathy After Solid Organ Transplantation: A Scoping Review

Rawashdeh,

Yaghmour,

Sulieman

et al. 2024

Annals of Medicine &Amp; Surgery

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Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy that causes temporary left ventricular wall motion abnormalities and abrupt reversible heart failure. The incidence of perioperative TTS is proportional to the severity of surgical trauma, the duration of the procedure, and the degree of apparent sympathetic activity. A growing number of articles have discussed TTS after solid organ transplant (SOT), which is one of the circumstances in which physical and emotional stress are at their highest levels. The majority of published cases involved patients who had received an orthotopic liver transplant (OLT). TTS occurred in 0.3-1.7% of liver transplant recipients, but a limited number of cases of TTS in patients who had received kidney, heart, or lung transplants have also been documented. In this study, we analyzed the TTS instances that developed after SOT, highlighting the symptoms and causes as well as the various treatment approaches that were applied. Most TTS cases following OLT and kidney transplant cases occurred in the first week of the surgery. However, the majority of cases occurred years after heart transplantation. Dizziness, dyspnea, and chest discomfort are the most typical symptoms. Patients may also experience syncope and generalized weakness. In spite of this, the symptoms differ depending on the transplanted organ. Dyspnea is a common symptom after lung transplants, whereas chest discomfort and dizziness are a common symptom after liver and kidney transplants. Yet, chest pain is not a typical symptom after a heart transplant.

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“…По данным Luu L.A. и соавт., опубликованным в 2020 г., постстрессовая, преходящая кардиомиопатия, сопровождающаяся выраженным снижением сократительной функции миокарда (Takotsubo syndrome), развивающаяся у 1,4 % оперированных пациентов, также может быть триггером возникновения тромбоза ПА [20].…”

Section: сосудистые осложненияunclassified

Echography in liver transplantation: a literature review

Донова¹,

Новрузбеков²,

Магомедов³

2021

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Liver transplantation is rightly considered the only radical treatment for terminal chronic liver diseases and patients with acute liver failure. However, despite the accumulated experience in the management of patients in this group, the level of complications development remains at a fairly high level. The success of the correction of emerging pathological conditions largely depends on the timing of their diagnosis. Since complications developing after liver transplantation most often do not have specific clinical and biochemical manifestations, the use of imaging research methods plays a key role in assessing the state of the transplanted organ at all stages of the postoperative period. Among all instrumental methods, ultrasound examination using Doppler techniques, carried out hourly directly in the intensive care unit, with an accuracy of 97 % and a specificity of up to 100 %, makes it possible to detect vascular post-transplant complications as soon as possible. Their timely correction avoids the loss of the graft. The use of dynamic observation contributes to differential diagnosis in identifying non-vascular complications at different stages of the postoperative period. The use of modern techniques greatly expands the possibilities of echography. Thus, the use of contrast enhancement not only shortens the study time, but also increases the sensitivity of Dopplerography in assessing the patency of the vascular bed, especially in patients with decreased central hemodynamics. The use of ARFI-elastography techniques in patients in the late postoperative period makes it possible to objectively assess the severity of hepatic graft fibrosis.

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Hepatic Artery Thrombosis and Takotsubo Syndrome After Liver Transplantation – Which Came First?

Cited by 6 publications

References 24 publications

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

A Comprehensive Review on Alcohol Abuse Disorder Fatality, from Alcohol Binges to Alcoholic Cardiomyopathy

Cardiomyopathy After Solid Organ Transplantation: A Scoping Review

Echography in liver transplantation: a literature review

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