2001
DOI: 10.1053/gast.2001.27103
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Hepatic autoantigens in patients with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy

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Cited by 108 publications
(84 citation statements)
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“…This is the first description of a putative target antigen in hepatitic GVHD. The development of anti-CYP1A2 antibodies concomitant with hepatitis similar to the autoimmune hepatitis seen in the APECED syndrome (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy) 6 and hydralazine-induced hepatitis, 7 in which CYP1A2 is an autoantigen, suggest that the identified antibodies are pathogenic, and CYP1A2 is an important target of immune responses in this case. It has been shown that cytochromes migrate in vesicles to the surface hepatocytes where they act as targets for autoantibodies.…”
mentioning
confidence: 68%
“…This is the first description of a putative target antigen in hepatitic GVHD. The development of anti-CYP1A2 antibodies concomitant with hepatitis similar to the autoimmune hepatitis seen in the APECED syndrome (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy) 6 and hydralazine-induced hepatitis, 7 in which CYP1A2 is an autoantigen, suggest that the identified antibodies are pathogenic, and CYP1A2 is an important target of immune responses in this case. It has been shown that cytochromes migrate in vesicles to the surface hepatocytes where they act as targets for autoantibodies.…”
mentioning
confidence: 68%
“…Patients with mutations in the autoimmune regulator gene develop the autoimmune polyglandular syndrome, and 10-15% of these develop AIH characterized by autoantibodies against cytochrome P450 2A6 and 1A2 [44][45][46] . Mice with a targeted mutation of the autoimmune regulator gene gene likewise show large spontaneous hepatic infiltrates of mononuclear cells and liver-specific autoantibodies that are under further characterization [47] .…”
Section: Gene-disrupted Animal Models Of Aihmentioning
confidence: 99%
“…This gene may alter thymic deletion of autoreactive T cells. 82 In Argentina and Brazil, children have the susceptibility allele DRB1*1301, which distinguishes them from adult counterparts. [83][84][85][86] This allele may influence their reactivity to environmental or infectious agents, such as hepatitis A, 31 which in turn may trigger autoimmune hepatitis.…”
Section: Autoimmune Hepatitis In Childrenmentioning
confidence: 99%