Hepatic blood flow in the rat: effect of portacaval shunt.

Ossenberg, F. W.; Denis, P; Benhamou, J P

doi:10.1152/jappl.1974.37.6.806

Cited by 59 publications

(13 citation statements)

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“…They assumed that 24 h after this procedure, the increase in the hepatic arterial flow was able to totally compensate portal blood diversion. The same study was performed by Ossenberg et al (13) in rats with portacaval shunt, 2 weeks after operation. At this time, there was a significant atrophy of the liver when com pared with sham-operated rats: BSP extraction was significantly lower in shunted rats; hepatic blood flow was significantly lower in shunted rats when related to body weight but no difference in hepatic blood flow related to liver weight was found between the two groups.…”

Section: Discussionmentioning

confidence: 78%

Effect of Portal Arterialization on Hepatic Cytochrome P-450 in Rats with Portacaval Shunt

Pector¹,

Verbeustel²,

Lambilliotte³

1975

Digestion

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Fractional clearance of colloidal gold particles (k), liver weight and hepatic cytochrome P-450 were measured in rats with portacaval shunt and in rats with portacaval shunt plus arterialization of the hepatic stump of the portal vein. The effects of enzyme induction by phenobarbital was studied in both groups. Total arterialization of the liver provides a probably normal hepatic blood flow and seems to protect the liver from post-shunt atrophy. Nevertheless, in both arterialized and shunted rats, the cytochrome P-450 concentration was significantly lower than in controls. The same results were obtained after treatment by phenobarbital. These findings suggest that normal hepatic blood flow and oxygen supply are not the main determinant of a normal activity of the hepatic microsomal bio transformation system. Substances present in portal blood would probably be necessary in maintaining hepatic cytochrome P-450 level.

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Section: Discussionmentioning

confidence: 78%

Effect of Portal Arterialization on Hepatic Cytochrome P-450 in Rats with Portacaval Shunt

Pector¹,

Verbeustel²,

Lambilliotte³

1975

Digestion

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“…Medium glucose and lactate concentrations were adjusted to 5 retool/1 and 2 mmol/l respectively. The flow rate was kept at a rate of 1.8 to 2.0ml-min -a -g liver -1, thus resembling physiological flow rates [13,14]. After an equilibration period of 45 min, samples were collected and hormones were infused into the portal vein for the indicated time periods.…”

Section: Liver Perfusionmentioning

confidence: 99%

Insulin-dependent inhibition of hepatic glycogenolysis by gastric inhibitory polypeptide (GIP) in perfused rat liver

1986

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Summary. The effect of porcine gastric inhibitory polypeptide on hepatic glycogen metabolism was investigated in the isolated in situ perfused rat liver. Glycogenolysis was stimulated by infusion of glucagon into the portal vein (half maximal effective portal vein concentration -30 pmol/1). When glucagon was infused at a final portal vein concentration of 0.5 nmol/1, simultaneous addition of insulin inhibited the glucagon-dependent glycogenolysis in a dose-dependent way (half maximal effective concentration for insulin about 2 nmol/1). Gastric inhibitory polypeptide alone at a concentration of 1 nmol/1 reduced glucagon-dependent glycogenolysis only slightly. However, when infused simultaneously at low insulin concentrations (0.1 nmol/1), gastric inhibitory polypeptide suppressed hepatic glucose production dose-dependently up to 70%. The data suggest that gastric inhibitory polypeptide exerts direct metabolic effects on hepatic glycogen metabolism predominantly in a situation where insulin is simultaneously present, e.g. following ingestion of glucose.

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“…The measurement of HBF by the Xenon washout technique [6,25] has been pre viously validated by comparison with elec tromagnetic flowmeter [18] or with direct flow measurement in perfused liver [23], The values of blood flow obtained in normal rats (1.74 ± 0.07 ml/min/g) are within the range obtained with various methods; with BSP [21] (2.0 ± 0.1 ml/min/g). with 131 I-MAA [16]: (2.0 ml/min/g).…”

Section: Discussionmentioning

confidence: 96%

Progressive Hepatic Arterial Flow Increase after End-to-Side Portacaval Shunt in Normal and Cirrhotic Rats

Secchi¹,

Hemptinne²,

Otté³

et al. 1986

Eur Surg Res

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Hepatic blood flow (HBF; ml/min/g of liver) has been measured in Wistar rats with a Xenon 133 washout method. The hepatic arterial blood flow (HABF) which amounts to 23 ± 3% of the total HBF increases immediately after occlusion of the portal vein to ensure 36 ± 4% of the control HBF, but continues to increase progressively for the next 4 h to furnish 69 ± 5% of the control HBF. This represents a 183 ± 16% increase of the control HABF. Thereafter, the liver starts to atrophy, whereas the total liver blood flow remains constant. Thus, the HBF increases and 30 days later does not differ significantly from the control value. Similar experiments were performed in rats in which cirrhosis was induced by CCl₄. The HBF is decreased and the contribution of the hepatic artery raised. After portacaval shunting, the increase of the HABF, although less pronounced, is also progressive and takes 4 h to reach its maximum.

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Hepatic blood flow in the rat: effect of portacaval shunt.

Cited by 59 publications

References 0 publications

Effect of Portal Arterialization on Hepatic Cytochrome P-450 in Rats with Portacaval Shunt

Effect of Portal Arterialization on Hepatic Cytochrome P-450 in Rats with Portacaval Shunt

Insulin-dependent inhibition of hepatic glycogenolysis by gastric inhibitory polypeptide (GIP) in perfused rat liver

Progressive Hepatic Arterial Flow Increase after End-to-Side Portacaval Shunt in Normal and Cirrhotic Rats

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