Hepatic concentrations of copper and other metals in dogs with and without chronic hepatitis

Cedeño, Yolanda; López‐Alonso, Marta; Miranda, Marta

doi:10.1111/jsap.12591

Cited by 18 publications

(20 citation statements)

References 33 publications

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“…In some cases, variations in these trace elements have been proposed as markers of disease and indicative of prognosis [ 30 , 31 ]. The most extensive information is available for Cu, and excessive Cu accumulation in the liver is known to occur in dogs suffering from hepatic disorders [ 3 , 4 , 5 , 6 , 7 , 8 ]. Serum copper concentrations are also higher in human patients suffering from hepatic disorders [ 31 ], and elevated Cu:Zn ratios have been proposed as markers of disease in patients with hepatic cirrhosis [ 31 ] or hepatocellular carcinoma [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

“…Although information in animals is scarcer, it is expected that trace elements are also involved in the pathogenesis of numerous diseases. For example, Cu [ 3 , 4 , 5 , 6 , 7 ] and other trace elements [ 8 ] are known to play a role in chronic hepatitis in dogs, and elevated concentrations of Fe and Cu (capable of inducing oxidative damage) have been detected in the brain tissues of Alzheimer’s patients and in the brains of humans and animals affected by other neurological disorders [ 9 , 10 ]. A recent study in dogs has suggested the role of Mn, Se and Zn in the pathophysiology and/or treatment of epilepsy, and that anti-convulsant therapy may affect Cu and Mo metabolism [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs

Cedeño

Miranda

Galdo

et al. 2020

Animals

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This study was designed (i) to establish reference ranges for the essential trace element and background levels of toxic element exposure in the healthy/normal dog population, and (ii) to evaluate whether trace element concentrations vary in dogs suffering from different pathologies. Blood serum samples were collected from 187 healthy and diseased dogs at the Veterinary Teaching Hospital, Faculty of Veterinary Medicine, University of Santiago de Compostela (northwest Spain). The samples were acid digested, and the concentrations of trace elements (Co, Cr, Cu, Fe, Mn, Mo, Ni, Se and Zn) and toxic elements (As, Cd, Hg and Pb) were determined by inductively coupled plasma-mass spectrometry (ICP-MS). This enabled us to establish reference ranges for the essential trace elements and the level of toxic element exposure in dogs, and to identify several clinical situations associated with variations in trace elements in serum. Relative to concentrations in healthy control dogs, statistically significant differences were observed in the concentrations of Cu (significantly higher in hepatic, inflammatory/infectious and oncological categories), Mo (significantly higher in renal category), Se (significantly lower in gastrointestinal category) and Zn (significantly lower in gastrointestinal, inflammatory/infectious and renal categories). Trace element concentrations can be a cause or consequence of disease, and the study findings indicate that trace element determination in serum provides useful information on the pathogenesis of certain diseases. Further research on the serum concentrations of trace elements, particularly in relation to other biochemical parameters and diagnostic tools, may provide valuable information for the diagnosis of diseases in dogs and the disease prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs

Cedeño

Miranda

Galdo

et al. 2020

Animals

Self Cite

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“…The increasing frequency of CH cases beginning in the late 1990s correlates with the change in the premixes used to supplement Cu in commercial dog foods, which resulted in higher amounts of bioavailable Cu in diets . The panel believes that the National Research Council (NRC) and Association of American Feed Control Officials dietary guidelines, along with a change to more bioavailable Cu chelate premixes in commercial dog food, are linked with an increased prevalence of hepatic Cu accumulation in dogs (Table ) .…”

Section: Etiologymentioning

confidence: 99%

“…correlates with the change in the premixes used to supplement Cu in commercial dog foods, which resulted in higher amounts of bioavailable Cu in diets. 8,21,36,46,120,121 The panel believes that the National Research Council (NRC) and Association of American Feed…”

Section: Drugs and Toxinsmentioning

confidence: 99%

ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

Webster

Cullen

Penninck

et al. 2019

Veterinary Internal Medicne

198

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This consensus statement on chronic hepatitis (CH) in dogs is based on the expert opinion of 7 specialists with extensive experience in diagnosing, treating, and conducting clinical research in hepatology in dogs. It was generated from expert opinion and information gathered from searching of PubMed for manuscripts on CH, the Veterinary Information Network for abstracts and conference proceeding from annual meetings of the American College of Veterinary Medicine and the European College of Veterinary Medicine, and selected manuscripts from the human literature on CH. The panel recognizes that the diagnosis and treatment of CH in the dog is a complex process that requires integration of clinical presentation with clinical pathology, diagnostic imaging, and hepatic biopsy. Essential to this process is an index of suspicion for CH, knowledge of how to best collect tissue samples, access to a pathologist with experience in assessing hepatic histopathology, knowledge of reasonable medical interventions, and a strategy for monitoring treatment response and complications.

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“…A intoxicação por cobre tem sido relatada tanto em humanos como em animais, principalmente na espécie ovina, a mais suscetível e frequentemente acometida [7,11,12]. Em cães, as manifestações clinicopatológicas da intoxicação por cobre são caracterizadas, basicamente, por um quadro de insuficiência hepática crônica, fazendo da crise hemolítica, tão comum em ovinos intoxicados por cobre, uma síndrome raramente associada à intoxicação na espécie canina, existindo apenas ocasionais descrições na literatura veterinária a cerca dessa manifestação [2,3,6,11,17]. O objetivo deste relato é descrever um caso de crise hemolítica em um cão com hepatite crônica associada ao cobre.…”

Section: Introductionunclassified

Vaginal Squamous Cell Carcinoma in a Nelore cow

Paula

Pupin

2019

Acta Scientiae. Vet.

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Background:Copper is an essential micronutrient for the body to function properly. However, although it is a vital element, an excess of copper in the body is extremely toxic. Copper toxicity has been reported mainly in sheep. In dogs, clinicopathological signs of toxicity are characterized by chronic liver failure. This means that the hemolytic crisis so common in sheep is a condition rarely associated with toxicity in dogs, so there are very few descriptions of this condition in the veterinary literature. The purpose of this report is to describe a case of hemolytic crisis in a dog with copper-associated chronic hepatitis. Case: A medium-sized 6-year-old bitch was brought to the Veterinary Hospital of the Federal University of Santa Maria, with clinical presentation of apathy, anorexia and red urine. A physical examination revealed mildly jaundiced mucosa and dark brown urine. A urinalysis indicated the presence of protein, bilirubin and occult blood. The blood count revealed hypochromic macrocytic anemia, leukocytosis due to left shift neutrophilia and thrombocytopenia. Serum biochemistry showed elevated levels of alanine aminotransferase and alkaline phosphatase. The animal was given a blood transfusion due to the severity of her anemia, but her clinical condition worsened and she died, whereupon her body was sent for necropsy. This necropsy revealed conspicuous signs of jaundice, splenomegaly and altered liver and kidney color. The liver was brownish, with its natural surface firm and slightly irregular. The kidneys were diffusely blackened. The urine was dark brown. Fragments of different organs were collected, fixed in 10% buffered formalin solution, routinely processed for histopathology and stained with hematoxylin and eosin. A histological dissection of the liver showed the hepatic lobes dissected by fibrosis, forming islands of hepatocytes and numerous lymphocytes and plasmocytes. Brown granular pigment was observed in periportal hepatocytes. Perls Prussian blue and rubeanic acid staining techniques were performed to characterize this pigment.

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Hepatic concentrations of copper and other metals in dogs with and without chronic hepatitis

Abstract: Dogs with chronic hepatitis not only have increased concentrations of copper in the liver but also increased concentrations of cobalt, manganese and zinc; measurement of these elements may perhaps aid in diagnosis of liver disease in dogs.

Cited by 18 publications

References 33 publications

Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs

Serum Concentrations of Essential Trace and Toxic Elements in Healthy and Disease-Affected Dogs

ACVIM consensus statement on the diagnosis and treatment of chronic hepatitis in dogs

Vaginal Squamous Cell Carcinoma in a Nelore cow

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