Hepatic Cryotherapy: Double-Freeze Cycles Achieve Greater Hepatocellular Injury in Man

Gj, Stewart; Preketes, A. P.; Horton, Matthew; Ross, William; Morris, David L.

doi:10.1006/cryo.1995.1021

Cited by 95 publications

(35 citation statements)

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“…In contrast to clinical experience neither clinical signs nor laboratory results pointed to the incidence of a 'cryoshock phenomenon' in our series [21,22,33]. In particular, a decrease in the thrombocyte count observed by others [17,19,20] was not seen.…”

Section: Laboratorycontrasting

confidence: 99%

“…Although there are data in the literature showing a more complete necrosis after multiple freeze/thaw cycles [22,[27][28][29], our in vivo study failed to reveal any significant differences. Our results are supported by a previous study by Weber et al [30] in which no advantages of a second freeze/thaw cycle were found.…”

Section: Safety and Efficacycontrasting

confidence: 95%

“…In addition, unforeseen damage to other liver structures or changes in hepatic function tests, blood count, etc., are possible [17][18][19][20]. Another potential complication is the so-called 'cryoshock phenomenon' [21,22].…”

Section: Introductionmentioning

confidence: 99%

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Hepatic Cryotherapy Involving the Vena cava

Eggstein

Neeff²,

Szarzynski³

et al. 2003

Eur Surg Res

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Liver tumors located near the retrohepatic vena cava are often considered nonresectable. For these patients cryoablation could be a therapeutic option. In this study the safety and efficacy of hepatic cryosurgery involving the retrohepatic vena cava were investigated. Cryolesions involving the vena cava were created in 26 pigs. Follow-up was 24 h and 14 days. The extent of the cryolesion, damage to the vena cava and complications were assessed after autopsy. The cyronecrosis extended into the wall of the vena cava in 81% of the animals. All animals had an uneventful recovery without any complications such as ruptures of the vessel, thrombosis or pulmonary embolism. Microscopically elastic and collagenous fibers of the cava wall remained intact. The continuity of the vessel wall was conserved. In conclusion, the safety and efficacy of cryosurgical treatment involving the retrohepatic vena cava were shown in a pig model.

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Section: Laboratorycontrasting

confidence: 99%

Section: Safety and Efficacycontrasting

confidence: 95%

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Hepatic Cryotherapy Involving the Vena cava

Eggstein

Neeff²,

Szarzynski³

et al. 2003

Eur Surg Res

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show abstract

“…49 (5) Larger catheter tip dimensions (6 mm and 8 mm) have been associated with increased procedural and long-term efficacy (ie, 2.5-fold lower recurrence rate with a 6-versus 4-mm electrode tip).…”

Section: Av Nodal Reentrant Tachycardiamentioning

confidence: 99%

Catheter Cryoablation

Andrade

Khairy

Dubuc

2013

Circ: Arrhythmia and Electrophysiology

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“…Hepatic cryosurgery uses insulated probes containing liquid nitrogen to destroy tumors by subzero temperature. In various small series, the 2-year survival rate was 15-65% with operative deaths under 4% and morbidity rates between 8% and 20% [30][31][32][33] rapid freezing and direct vascular injury from probe insertion [31,34,35]. Double freeze/thaw cycle cryotherapy resulted in most patients in marked thrombocytopenia, which may be responsible for the coagulopathy seen in these cases [32,36].…”

Section: Other Combined Surgical Treatment Modalitiesmentioning

confidence: 99%

Surgical and Multimodality Treatment of Colorectal Liver Metastases

Schlag¹,

Benhidjeb²,

Kilpert³

1999

Oncol Res Treat

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For patients with colorectal liver metastases, surgery offers the only possibility for cure. The achievable mean 5-year survival rate is 30%, and the 5-year disease-free survival rate approximately 15%. Due to refinement in operative and anesthetic techniques, improved critical care with a decrease in morbidity (< 30%) and mortality (< 5%), hepatic resection is a safe and efficient procedure. However, only 10–15% of patients with colorectal liver metastases can undergo potentially curative liver resection. Therefore, accurate staging is an important prerequisite in selecting patients who would benefit from surgery. Today, the most generally accepted contraindication for liver resection is the presence of discontinuous extra-hepatic spread and more than 4 metastases. Recurrence of hepatic metastases after potentially curative resection is observed in over 50% of cases. Re-resection of recurrent liver metastases can be beneficial in a carefully selected group of patients with limited disease. Multimodal neoadjuvant therapy is a promising tool for patients with colorectal liver metastases initially considered not R0-resectable. Cryosurgery and laser-induced thermotherapy are additive methods that may help to improve surgical treatment results in the future. Improvement in clinical outcome and survival can be achieved.

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Hepatic Cryotherapy: Double-Freeze Cycles Achieve Greater Hepatocellular Injury in Man

Cited by 95 publications

References 0 publications

Hepatic Cryotherapy Involving the Vena cava

Hepatic Cryotherapy Involving the Vena cava

Catheter Cryoablation

Surgical and Multimodality Treatment of Colorectal Liver Metastases

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